PROGNOSTICATION OF THE FREQUENCY OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE EXACERBATION COMBINED WITH THE ISHEMIC HEART DISEASE

Abstract

The possibilities of prognostication of frequent exacerbation of chronic obstructive pulmonary disease (COPD) combined with the ischemic heart disease (IHD) by the estimation of parameters of system inflammation in blood plasma (С-reactive protein, TNF-α, IL-6, IL-8, leukocytes, fibrinogen) and anti-inflammatory IL-4 were studied. Complex clinical and laboratory examination of 88 COPD patients with IHD was done. 36 patients during 12 months were found to have an acute form of COPD for no more than 2 times (the first group), and 52 patients had it for more than two times (the second group). It was found out that in the patients of the second group the concentration of biomarkers of system inflammation was significantly higher than in the patients of the first group. Statistically important differences were revealed in the content of C-reactive protein (3.78±0.14 and 3.21±0.11 g/l, respectively, р<0.05), TNF-α (7.64±0.32 and 4.92±0.22 pg/l, respectively, р<0,001), IL-8 (19.73±1.19 and 15.90±1.21 pg/l, respectively, р<0.05). At the same time the level of IL-4 in the second group was lower than in the first group (6.12±0.10 and 8.23±0.65 pg/l, respectively, р<0.01). On the basis of the revealed regularities the method of prognostication of frequent COPD exacerbation combined with IHD was offered with the help of integral estimation of the mentioned parameters by doing the discriminant equation. This mathematical model of prognostication is a simple and accessible method which allows to make a decision about individual treatment and prophylaxis in such-like patients.