THE CHANGE OF UTERINE BLOODFLOW AND UTRASOUND STRUCTURE OF FETOPLACENTAL COMPLEX AT INFLUENZA А(Н3N2) IN THE SECOND TRIMESTER OF PREGNANCY

Abstract

The bloodflow in the uterine arteries, echo structure of fetoplacental complex, biochemical and hormonal parameters in 121 women in the second trimester of pregnancy at influenza A(H3N2) at the height of the disease were studied. 58 women had antibody titer to the pathogen 1:8-1:32 (the first group), 63 women had the titer 1:32-1:128 (the second group). The control group had 40 women with physiological course of pregnancy. It was found out the patients of the second group in comparison with the patients of the first group had a reliable increase of resistance in the right uterine artery (2.52±0.052 and 2.34±0.063 standard units, respectively, р<0.05), statistically reliable increase of the detection frequency of uterine hypertonus (20.6 and 5.2%, respectively, р<0.05), placenta thickening (22.2 and 6.9%, respectively, р<0.05) and cord entanglement around the neck of the fetus (19.1 and 2.2%, respectively, р<0.05). These changes in the patients of the second group were diagnosed against the growth of mean molecular peptides content in the blood plasma and activation of the process of lipid peroxidation which leads to the increase of malonic dialdehyde concentration and to the decrease of ά-tocopherol content. At the higher titer of anti-influenza antibodies the depression of hormonopoiesis in fetoplacental complex was confirmed with the decrease of concentration of chorionic gonadotropin, placental lactogen, progesterone, estriol, dehydroisoandrosterone, which was diagnosed at the growth of serotonin and cortisol concentration. It was found out that the growth of antivirus antibody titer, endotoxins, the products of lipid peroxidation reaction and serotonin as well as the imbalance of sex hormones causing the change of the vascular tonus and alternative changes of the wall of uterine -placental blood vessels plays an important role in the change of blood flow at the level of uterine arteries and ultrasound picture of fetoplacental system.