FEATURES OF MORPHOFUNCTIONAL CHANGES IN PLACENTA IN PREGNANT WOMEN WITH CHRONIC VIRAL HEPATITIS B AND C

Abstract

The features of gestational period and of labour as well as morphofunctional state of placenta in women with chronic viral hepatitis B and C were studied. Retrospective analysis of 1336 labour histories including 534 pregnant women with viral hepatitis B and 788 pregnant women with viral hepatitis C and 14 pregnant women with the combination of viral hepatitis B and C was done. 1004 labour histories of pregnant women whose gestational period and labour were without complications were included in the group of comparison. All pregnant women had general clinical examination, identification of markers (antigens/antibodies) of hepatitis B and C in the blood serum; histological study of 100 placentas in pregnant women with viral hepatitis and 100 placentas in healthy pregnant women was done. The study proves convincingly that viral hepatitis B and viral hepatitis C have a negative influence on the course of pregnancy, labour and fetus development. The course of pregnancy with viral hepatitis unlike healthy pregnant women is statistically oftener complicated with gestosis (in 43.68±1.35 and 19.52±1.25%, respectively, р<0.0001), miscarriage threat (in 48.02±1.37 and 20.72±1.28%, respectively, р<0.0001), fetoplacental insufficiency (in 49.96±1.37 and 10.05±0.95%, respectively, р<0.0001). Histological signs of fetoplacental insufficiency were found in all pregnant women with viral hepatitis B and C, a severe form of placental insufficiency was revealed in 32% of pregnant women. Pregnant women with chronic viral hepatitis B and C had perinatal morbidity statistically oftener than the women in the control group.