EFFECTIVENESS OF VARIABILITY OF THYROID STIMULATING HORMONE LEVELS IN THE BLOOD AT THE ESTIMATION OF THE CHANGED RESPONSIVENESS OF BRONCHI IN ASMATHICS

The aim of the research was to define pathognomonic changes of hormonal profile of the system «hypothesis-thyroid gland» for the development of thyroid insufficiency in patients with uncontrolled bronchial asthma and the estimation of their role in the formation and realization of cold bronchospasm. 124 patients with bronchial asthma without evident pathology of thyroid gland and 25 practically healthy people simultaneously were examined upon the primary serum levels of thyroid stimulating hormone (TSH), general thyroxin (Т₄), general triiodothyronine (Т₃) and free fractions of these hormones (сТ₄ и сТ₃), and in 60 minutes after bronchoprovocation challenge with cold air. Most patients (73%) had the changes of the functional state of the thyroid gland which in 48% were revealed through the decrease of Т₄ products in the range of «highly normal» values of TSH in the blood: from 2.5 till 4.0 mUn/l, and in 25% from 4.0 till 10 mUn/l in the form of «light» hypothyroidism of I and II degree respectively; the values increased alongside with the growth of cold hyperresponsiveness of bronchi. At the same time there was an initiating influence of cold hyperresponsiveness of bronchi on the compensatory growth of thyrotropin and acceleration of the conversion of thyroid hormones into the most active forms of hormones – Т₃ и сТ₃. The realization of this phenomenon was more characteristic for the patients with bronchial asthma with the TSH value levels in the range from 2.5 till 4.0 mUn/l (I degree of thyropathy) than in patients with the level of TSH from 4.0 till 10.0 mUn/l (II degree of thyropathy).

бронхиальная астма, гормоны гипофизарно-тиреоидной системы, реактивность бронхов, bronchial asthma, hormones of hypothesis and thyroid system, bronchi responsiveness

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