PREDICTIVE ROLE OF CYCLIC ADENOSINEMONOPHOSPHATE AND PLASMA CORTISOL IN THE DEVELOPMENT OF COLD AIR INDUCED BRONCHOCONSTRICTION IN ASTHMATICS
Abstract
The phenomenon of cold bronchial hyperresponsiveness represents an urgent clinical problem because of its high prevalence in asthmatics living in cold climate conditions and ability to promote the development of fluctuating bronchial obstruction. However, often its early diagnostics by cold bronchoprovocation challenge is not possible due to the technical limitations or the presence of medical contraindications. In this case indirect methods based on the detection of biomarkers associated with the development of cold bronchoconstriction may be useful. The aim of the present study was to examine the role of disturbance in glucocorticoid homeostasis and functional activity of β2-adrenergic receptor complex as the predictors of cold bronchial hyperresponsiveness in patients with bronchial asthma. Using logistic regression analysis we invented three mathematical models allowing to perform the forecast with the accuracy up to 83%. Detailed comparative characteristic of the diagnostic values has been provided for all the proposed methods.
About the Authors
Aleksey B. Pirogov
Far Eastern Scientific Center of Physiology and Pathology of Respiration SB RAMS
Russian Federation
Russian Federation
Denis E. Naumov
Far-Eastern Scientific Center of Physiology and Pathology of Respiration of Siberian Branch RAMS
Russian Federation
Russian Federation
Elena V. Ushakova
Far-Eastern Scientific Centre of Physiology and Pathology of Respiration of Siberian Branch RAMS
Russian Federation
Russian Federation
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Review
For citations:
Pirogov A.B., Naumov D.E., Ushakova E.V. PREDICTIVE ROLE OF CYCLIC ADENOSINEMONOPHOSPHATE AND PLASMA CORTISOL IN THE DEVELOPMENT OF COLD AIR INDUCED BRONCHOCONSTRICTION IN ASTHMATICS. Bulletin Physiology and Pathology of Respiration. 2012;(46):25-29. (In Russ.)
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