CHANGE OF LOCAL SPECIFIC PROTECTION AND CYTOKINE STATUS IN WOMEN IN THE FIRST TRIMESTER OF PREGNANCY AT THE ACUTE FORM OF CHRONIC BRONCHITIS CONDITIONED BY THE VIRUSES OF RESPIRATORY GROUP
Abstract
Specific humoral immunity to influenza virus А(Н3N2) and to viruses of the respiratory group, the concentration of serum secretory immunoglobulin А (sIgA), as well as pro- and anti-inflammatory cytokines (TNF-a, IFN-γ) were studied in 86 women with chronic bronchitis in the I trimester of gestation. It was found out that in the stage of remission pregnant women with chronic obstructive bronchitis in comparison with the patients with chronic non-obstructive bronchitis had in the blood serum influenza virus А(Н3N2) with antibody titer 1:64-1:64 (in 45 and 4%, respectively, р<0.05) and parainfluenza of the 1-3 types with antibody titer 1:128-1:128 (in 40 and 4%, respectively, р<0.05). Pregnant women with the exacerbation of chronic obstructive bronchitis in comparison with patients with exacerbation of non-obstructive bronchitis had influenza А(Н3N2) 4 times oftener and parainfluenza of the 1-3 types 10 times oftener; they also had a lower level of sIgA (5.5±0.15 and 6.5±0.32 pg/ml, respectively, р<0.05), as well as high content of TNF-a (58.1±3.9 and 45.4± 4.2 pg/ml, respectively, р<0.05) and IFN-γ (49.7±2.7 and 37.9±3.8 pg/ml, respectively, р<0.05). The obtained data shows the role of viruses of the respiratory group in the suppression of local specific protection as well as in more intensified systematic inflammatory reaction at the aexacerbation of chronic obstructive bronchitis in women in the I trimester of pregnancy.
About the Authors
Leonid G. Nakhamchen
Far Eastern Scientific Center of Physiology and Pathology of Respiration SB RAMS
Russian Federation
Russian Federation
Igor' N. Gorikov
Far Eastern Scientific Center of Physiology and Pathology of Respiration SB RAMS
Russian Federation
Russian Federation
Tat'yana E. Tal'chenkova
Amur Regional Clinical Hospital
Russian Federation
Russian Federation
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Review
For citations:
Nakhamchen L.G., Gorikov I.N., Tal'chenkova T.E. CHANGE OF LOCAL SPECIFIC PROTECTION AND CYTOKINE STATUS IN WOMEN IN THE FIRST TRIMESTER OF PREGNANCY AT THE ACUTE FORM OF CHRONIC BRONCHITIS CONDITIONED BY THE VIRUSES OF RESPIRATORY GROUP. Bulletin Physiology and Pathology of Respiration. 2012;(46):44-47. (In Russ.)
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