МЕТОДЫ АНАЛИЗА ПЕРЕКИСНОГО ОКИСЛЕНИЯ ЛИПИДОВ В МЕДИКО-БИОЛОГИЧЕСКИХ ИССЛЕДОВАНИЯХ

Представлен краткий обзор методов анализа продуктов свободно-радикального перекисного окисления полиненасыщенных жирных кислот, представляющих интерес для медико-биологических исследований состояний, сопровождающихся окислительным стрессом. Перекисное окисление липидов (ПОЛ) является следствием окислительного стресса и выражается в образовании многочисленных продуктов, различающихся по химической структуре, времени жизни, токсичности и биологической активности. Интенсивность ПОЛ существенно возрастает при многих патологических состояниях. Анализ продуктов ПОЛ представляет интерес для оценки уровня окислительного стресса в организме, для исследования токсического, метаболического и регулирующего действия этого процесса на организм, а также в диагностике некоторых заболеваний. Предложенные методы анализа продуктов ПОЛ различаются по специфичности, чувствительности, сложности исполнения и необходимого оборудования. В массовых клинических исследованиях предпочтение отдается менее трудоемким и специфичным методам анализа стабильных продуктов ПОЛ, хотя возрастающее применение физико-химических методов анализа, прежде всего масс-спектрометрии, делает возможным одновременный анализ широкого круга продуктов ПОЛ. Введение в практику высокоспецифичных антител делает иммуноферментный анализ многих крайне минорных и сложно определяемых продуктов ПОЛ рутинным занятием. Достоверность и точность анализа во многом определяются предпринятыми при отборе и хранении проб мерами, предотвращающими распад или дальнейшее образование продуктов ПОЛ в образце.

перекисное окисление липидов, гидроперекиси, изопростаны, альдегиды, методы анализа, lipid peroxidation, hydroperoxides, isoprostanes, aldehydes, analytical methods

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