INTERRELATION OF СLINICAL AND FUNСTIONAL PARAMETERS, SYSTEMIC INFLAMMATION IN THE DEVELOPMENT OF ARTERIAL RIGIDITY IN PATIENTS WITH BRONCHIAL ASTHMA
Abstract
The aim of the study is to research the interrelation of clinical and functional indices, systemic inflammation in the development of arterial rigidity in the patients with bronchial asthma. We examined 220 patients, among them 106 patients with moderate bronchial asthma and 61 persons with severe bronchial asthma and 53 patients with steroid-dependent bronchial asthma. The control group consisted of 40 healthy volunteers. We studied the parameters of lung function, arterial rigidity, and also the levels of TNF-α, IL-6, sCD31, C-reactive protein in blood plasma in patients with bronchial asthma in the period of exacerbation and in 12 months (out of exacerbation). The growth of IL-6 and TNF-α levels was revealed in patients in the period of exacerbation in comparison with the control (р<0.05), which proved the existence of the systemic inflammatory response. IL-6 is the most informative parameter that reflects the stage of the disease in the patients with bronchial asthma of moderate or severe clinical course. The increase of sCD31 levels in blood plasma of patients of all groups was found out. It suggests the endothelial cells damage. In patients with bronchial asthma there is the growth of aorta rigidity revealed through the increase of a pulse wave rate in the aorta and augmentation index; it aggravates along with the severity of bronchial asthma. The age and disease prescription are the most important factors that influence the change of a pulse wave rate in the aorta and of augmentation index.
About the Authors
Elena A. Sobko
Krasnoyarsk State Medical University
Russian Federation
Russian Federation
Angelina Yu. Kraposhina
Krasnoyarsk State Medical University
Russian Federation
Russian Federation
Olga P. Ischenko
Krasnoyarsk State Medical University
Russian Federation
Russian Federation
Irina V. Demko
Krasnoyarsk State Medical University
Russian Federation
Russian Federation
Alla B. Salmina
Krasnoyarsk State Medical University
Russian Federation
Russian Federation
Lyudmila V. Kraposhina
Town Outpatients Clinic №4
Russian Federation
Russian Federation
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Review
For citations:
Sobko E.A., Kraposhina A.Yu., Ischenko O.P., Demko I.V., Salmina A.B., Kraposhina L.V. INTERRELATION OF СLINICAL AND FUNСTIONAL PARAMETERS, SYSTEMIC INFLAMMATION IN THE DEVELOPMENT OF ARTERIAL RIGIDITY IN PATIENTS WITH BRONCHIAL ASTHMA. Bulletin Physiology and Pathology of Respiration. 2013;(47):26-30. (In Russ.)
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