ТРАНСПОРТ ЛИПИДОВ В ФЕТОПЛАЦЕНТАРНОМ БАРЬЕРЕ С ПОМОЩЬЮ ЛИПИДПЕРЕНОСЯЩИХ БЕЛКОВ H-FABP У БЕРЕМЕННЫХ С ОБОСТРЕНИЕМ ЦИТОМЕГАЛОВИРУСНОЙ ИНФЕКЦИИ В ТРЕТЬЕМ ТРИМЕСТРЕ ГЕСТАЦИИ

В работе проанализированы теоретические концепции о транспорте жирных кислот, а также представлены собственные данные. Изучен характер переноса жирных кислот с помощью липидпереносящих белков (H-FABP) в синцитиотрофобласте ворсинок плаценты при обострении цитомегаловирусной инфекции в третьем триместре беременности. Обследовано 25 беременных в третьем триместре гестации с обострением цитомегаловирусной инфекции при росте титра антител класса G 1:800 (основная группа), и 20 беременных, не болевших на протяжении всего периода гестации (контрольная группа). Титр антител класса М и G к цитомегаловирусу и индекс авидности определяли иммуноферментным методом, измерение содержания липидпереносящего белка проводили на спектрофотометре. Гистохимическая реакция на определение активности перекисного окисления в синцитиотрофобласте и эндотелии кровеносных сосудов пуповины выполнялась методом Винклера-Шульце. Количественное содержание перекисей проводилось методом компьютерной цитофотометрии. Установлено, что при обострении цитомегаловирусной инфекции у беременных в третьем триместре гестации снижается поступление в синцитиотрофобласт ворсинок плаценты липидпереносящих белков. Отмечается избирательная передача жирных кислот через внутреннюю мембрану синцитиотрофобласта в пуповинную кровь плода. При обострении у беременных цитомегаловирусной инфекции в крови плода снижается количество противовоспалительных жирных кислот семейства ω-3 и, напротив, увеличивается поступление провоспалительных жирных кислот семейства ω-6 и арахидоновой кислоты.

цитомегаловирусная инфекция, плацента, липидпереносящие белки, жирные кислоты, cytomegalovirus infection, placenta, fatty acid, lipid-transfer proteins

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