LIPIDS TRANSPORTATION WITHIN FETOPLACENTAL BARRIER WITH THE HELP OF H-FABP LIPID-TRANSFER PROTEINS IN PREGNANT WOMEN WITH THE EXACERBATION OF CYTOMEGALOVIRUS INFECTION IN THE THIRD TRIMESTER OF PREGNANCY

The work deals with theoretical conceptions about fat acids transportation as well as personal investigation data. The character of fat acids transportation was studied with the help of lipid- transfer proteins H-FABR in the syncytiotrophoblast of placenta villi at the exacerbation of cytomegalovirus infection in the third trimester of pregnancy. 25 pregnant women in the third trimester of gestation with the exacerbation of cytomegalovirus infection at the growth of antibodies titer of G 1:800 class (the main group) and 20 women who were not sick for the whole period of gestation (the control group) were examined. Antibodies titer of M and G class to cytomegalovirus and avidity index were found by immune-enzyme method; the measurement of lipid-transfer protein content was done at spectrophotometer. The histochemical reaction to find out the activity of peroxidation in the syncytiotrophoblast and umbilical cord blood vessels endothelium was done by Winkler-Schulz method. The quantitative estimation of peroxides was conducted with the computer cytophotometry method. It was found out that at the exacerbation of cytomegalovirus infection in pregnant women in the third trimester of gestation there is a decrease of lipid-transfer proteins into syncytiotrophoblast of placenta villi. There is also a selective transportation of fat acids through inner membrane of syncytiotrophoblast into the fetus umbilical blood. At the exacerbation of cytomegalovirus infection in pregnant women there is a drop of anti-inflammatory fat acids of ω-3 family and vice versa there is an increase of anti-inflammatory acids of ω-6 family and arachidonic acid.

цитомегаловирусная инфекция, плацента, липидпереносящие белки, жирные кислоты, cytomegalovirus infection, placenta, fatty acid, lipid-transfer proteins

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