ТРАНСПОРТ ЖИРНЫХ КИСЛОТ ЧЕРЕЗ МЕМБРАНУ (ОБЗОР ЛИТЕРАТУРЫ)
Аннотация
Докозагексаеновая и арахидоновая кислоты чрезвычайно важны для нормального развития плода во время беременности. Поскольку они не могут быть синтезированы плодом и плацентой, то обеспечение ими происходит путем транспорта через плаценту из материнской крови. В обзоре литературы рассмотрен механизм поступления длинноцепочечных жирных кислот, происходящий по двум путям: пассивная диффузия через мембрану и транспорт с помощью специальных белков. К последним относятся FABPpm/GOT2, FABP, FATP, кавеолин-1 и FAT/CD36. Большой раздел статьи посвящен особенностям поставки жирных кислот при беременности. Он включает в себя три этапа: диссоциация с белковым комплексом, транспорт через плазматическую мембрану и связывание их с внутриклеточными белками. Важную роль в избирательности поступления докозагексаеновой и арахидоновой кислот играют: pFABPpm, локализованный на плазматической мембране материнской стороны плаценты, FATP-1 и FATP-4. FABP направляют жирные кислоты в различные точки внутри синцитиотрофобласта или в плазму пуповины. Сделан вывод, что поступление длинноцепочечных жирных кислот к плоду является результатом комбинированных процессов, протекающих у матери и в фетоплацентарном комплексе.
Ключевые слова
Об авторах
Инна Викторовна Довжикова
Дальневосточный научный центр физиологии и патологии дыхания Сибирского отделения РАМН
Россия
Россия
Михаил Тимофеевич Луценко
Дальневосточный научный центр физиологии и патологии дыхания Сибирского отделения РАМН
Россия
Россия
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Рецензия
Для цитирования:
Довжикова И.В., Луценко М.Т. ТРАНСПОРТ ЖИРНЫХ КИСЛОТ ЧЕРЕЗ МЕМБРАНУ (ОБЗОР ЛИТЕРАТУРЫ). Бюллетень физиологии и патологии дыхания. 2013;(50):130-138.
For citation:
Dovzhikova I.V., Lutsenko M.T. MEMBRANE FATTY ACIDS TRANSPORT (REVIEW). Bulletin Physiology and Pathology of Respiration. 2013;(50):130-138. (In Russ.)
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