SYSTEM ESTIMATE OF IMMUNEMETABOLIC DISTURBANCES AND THE WAYS TO CORRECT THEM IN COPD PATIENTS OF SENIOR AGE GROUPS

The aim of the research is to study the features of functioning and the character of intra-systemic and cross-systemic integrations of immune and prooxidant-antioxidant system in patients of senior age with COPD to justify the approaches to the correction of correlations between these homeostatic systems with the use of ozone therapy. The parameters of the immune system and the system «lipid peroxidation-antioxidant protection» were studied in people of senior age (75 years and older) including 28 healthy patients and 23 COPD patients in the remission stage. It was found out that the main metabolic features of COPD remission in people of senior age are the disorders of the immune system with the decrease of its functional reserves and the disbalance of the system «lipid peroxidation-antioxidant protection». The presence of COPD led to 3.5 times increase of the number of cross-system relationships in comparison with healthy people. The quantity of direct and reverse correlations was almost equal unlike the group of healthy people where reverse correlations dominated (62%). When the number of strong and medium correlations decreased from 100 till 39.1%, there was an increase of the number of weak correlations from 0 till 60.9%. The number of intra-systemic correlations in the immune system and in the system «lipid peroxidation-antioxidant system» did not have any serious changes in the group of healthy people. There was an increase of weak correlations from 0 till 15.7% in the total number of correlations among the patients. The domination of strong correlations in the group of healthy people tells about a serious stability of systems, in particular the immune system, in comparison with the group of COPD patients. Thus the change of the number of correlations, their strength and intensity, in comparison with somatically healthy people, shows disintegration in the correlations of the immune and metabolic systems under the pathology. The obtained results allow to learn more about integrative correlations of these two systems under COPD remission and to prognosticate the responsiveness of the old organism to the use of ozone therapy which affects the immune balance of the body through the influence on its oxidative-reduction potential.

ХОБЛ, иммунометаболические нарушения, старшие возрастные группы, COPD, immune-metabolic disorders, senior age groups

1. Анисимов В.Н. Молекулярные и физиологические механизмы старения: в 2-х т. Спб.: Наука, 2008. Т.1. 481 с.

2. Визель И.Ю., Пронина Е.Ю., Визель А.А. Патогенетическая терапия хронической обструктивной болезни лёгких: поиск решений // Consilium Medicum. 2010. Т.12, №11. C.43-46.

3. Иванов Е.М., Исаченко Е.Г., Калинина Е.П. Нарушение межсистемных взаимодействий при хроническом воспалительном процессе // Мед. иммунол. 2007. №6. С.581-588.

4. Нарушение метаболического статуса у пациентов с хронической обструктивной болезнью легких / Е.П.Калинина [и др.] // Тер. арх. 2007. Т.79, №3. С.15-17.

5. Медицинские лабораторные технологии и диагностика: справочник / под ред. А.И.Карпищенко. СПб.: Интермедика, 1999. 656 с.

6. Оценка антиокислительной активности плазмы крови с применением желточных липопротеидов / Г.И.Клебанов [и др.] // Лаб. дело. 1988., №5. С.59-62.

7. Конторщикова К.Н., Ефременко Ю.Р., Окрут И.Е. Биологические механизмы эффективности озонотерапии // Озон в биологии и медицине: материалы 7 всерос. науч.-практ. конф. Н. Новгород, 2007. С.3-5.

8. Крутько В.Н., Гаврилов М.А., Донцов В.И. Исследование изменений системной интеграции функций при старении у женщин // Вестн. восстанов. мед. 2012. №4. С.65-67.

9. Малявин А.Г., Епифанов В.А., Глазкова И.И. Реабилитация при заболеваниях органов дыхания. М.: ГЭОТАР-Медиа, 2010. 352 с.

10. Свободнорадикальные процессы и воспаление (патогенетические, клинические и терапевтические аспекты) / Т.Г.Сологуб [и др.]. М.: Академия естествознания, 2008. 143 с.

11. Стручков П.В. Скрининг-тест для оценки патогенных свойств циркулирующих иммунных комплексов // Лаб. дело. 1985. №7. С.410-412.

12. Хавинсон В.Х., Коновалов С.С. Избранные лекции по геронтологии. СПб.: Прайм-ЕВРОЗНАК, 2009. 896 с.

13. Чучалин А.Г. Хроническая обструктивная болезнь легких. М.: Атмосфера, 2008. 568 с.

14. Шмелев Е.В., Бумагина Т.К., Митеров Г.Г. Модификация метода Park // Лаб. дело. 1979. №9. С.13-15.

15. Bocci V. Ozone. A new medical drug. 2nd ed. Netherlands, Dordrecht: Springer, 2011. 315 р.

16. Inflammaging and anti-inflammaging: a systemic perspective on aging and longevity emerged from studies in humans / C.Franceschi [et al.] // Mec. Ageing Dev. 2007. Vol.128, №1. P.92-105.

17. Mancini G., Carbonara А.О., Heremans J.S. Immunochemical quantitation of antigen by simple radial immunodiffusion // Immunochemistry. 1965. Vol.2, №3. P.235-254.