APPLICATION OF COMPUTER-AIDED TOMOGRAPHY WITH 3D VOLUMETRY IN THE DISAGNOSE OF LUNG FUNCTION DISORDERS IN PATIENTS WITH BRONCHIAL ASTHMA

Modern radiodiagnostics plays an important role in diagnosing of a wide range of bronchopulmonary diseases. The application of roentgen functional methods for the study of bronchial asthma course is becoming more popular due to the increasing prevalence of the disease. To study the possibilities of the method of computer-aided tomography with 3D volumetry in the diagnose of the lung function disorders, 136 patients with bronchial asthma of different severity and 16 healthy people were examined. The program of study included computer-aided tomography with inspiratory-expiratory test, spirography and bodyplethysmography. The obtained data of computer-aided tomography were processed with the help of our own method of 3D volumetry which allows to a quantify the estimation of lung ventilation disorders. While analyzing the data it was possible to find the correlation between functional methods of the research and volumetry: the indices of lungs inflation in asthmatics correlate with the data obtained with functional methods of the research (spirography and bodyplethysmography), which allows to use them in practical estimation of disorders of lung function. The obtained parameters of expiratory inflation of lungs in patients with bronchial asthma were different from the parameters of healthy people and increased depending on the severity of the disease. The quantitative criteria of lungs hyperinflation diagnose were developed. The results of the research prove the effectiveness of the method of 3D-volumetry in the diagnose of disorders of the lung function in patients with bronchial asthma.

бронхиальная астма, нарушение вентиляционной функции легких, компьютерная томография, трехмерная волюметрия, экспираторная воздухонаполненность, bronchial asthma, lung function disorders, computer-aided tomography, 3D volumetry, expiratory hyperinflation

1. Новый метод лучевой диагностики нарушений вентиляционной функции легких посредством мультиспиральной компьютерной томографии / А.В.Ильин [и др.] // Бюл. физиол. и патол. дыхания. 2013. Вып.47. С.41-47

2. Леншин А.В. Разработка и клиническое применение методов рентгенофункционального исследования легких // Бюл. физиол. и патол. дыхания. 2004. Вып.16. С.6-11.

3. Bankier A.A., O’Donnell C.R., Boiselle P.M. Quality initiatives. Respiratory instructions for CT examinations of the lungs: a hands-on guide // Radiographics. 2008. Vol.28, №4. P.919-931.

4. A multivariate analysis of risk factors for the air-trapping asthmatic phenotype as measured by quantitative CT analysis / A.Busacker [et al.] // Chest. 2009. Vol.135, №1. P.48-56.

5. High-resolution computed tomography evaluation of airway distensibility in asthmatic and healthy subjects / A. Castagnaro [et al.] // Radiol. Med. 2008. Vol.113, №1. P.43-55.

6. Lung imaging in asthma: the picture is clearer / M.Castro [et al.] // J. Allergy Clin. Immunol. 2011. Vol.128, №3. P.467-478.

7. Franquet T. Técnicas de imagen en la exploración de la vía aérea pequeña: asma y EPOC // Arch. Bronconeumol. 2011. Vol.47, №2. P.20-26.

8. Uncomplicated asthma in adults: comparison of CT appearance of the lungs in asthmatic and healthy subjects / D.A.Lynch [et al.] // Radiology. 1993. Vol.188, №3. P.829-833.

9. Quantitative assessment of air trapping in chronic obstructive pulmonary disease using inspiratory and expiratory volumetric MDCT / S. Matsuoka [et al.] // Am. J. Roentgenol. 2008. Vol.190, №3. P.762-769.

10. Radiological approach to asthma and COPD - the role of computed tomography / Y.Nakano [et al.] // Allergol. Int. 2009. Vol.58, №3. P.323-331.

11. Clinical assessment of airway remodeling in asthma: utility of computed tomography / A.Niimi [et al.] // Clin. Rev. Allergy Immunol. 2004. Vol.27, №1. P.45-58.

12. Stern E.J., Frank M.S. Small-airway diseases of the lungs: findings at expiratory CT // Am. J. Roentgenol. 1994. Vol.163, №1. P.37-41.