THE ESTIMATION OF ARTERIAL STIFFNESS IN THE PATIENTS WITH COPD AND BRONCHIAL ASTHMA

The purpose of our research is to study arterial stiffness in patients with COPD III, IV and patients with severe bronchial asthma (BA). The study was of a prospective and observational character and lasted for 52 weeks. Basic characteristics of arterial stiffness, lung function indices and oxygen saturation were identified. 65 people were involved in the research: 17 patients with severe BA (the first group), 14 patients with a severe COPD (the second group), 17 patients with a very severe COPD (the third group). The group of control included 17 practically healthy volunteers. The increase of the main indices of arterial stiffness (the pulse wave velocity in aorta and augmentation index) was found regardless the period of observation in all the groups (р<0.05). Statistically significant increase of ejection period was revealed in the patients of 2 and 3 groups, which shows the decrease of myocardial contractility of the left ventricle regardless the phase of the disease. The patients of the first group were found to have a positive correlation between the level of the pulse wave velocity in the aorta and the duration of the disease (r=0.62; p=0.008). In the 2 group during exacerbation positive correlations between the period of smoking and the pulse wave velocity in the aorta (r=0.57; p=0.03), the parameters of central blood pressure (r=0.61; p=0.02) and peripheral blood pressure (r=0.65; p=0.011) were found. Patients with very severe COPD had a decrease of contractility of the left ventricle, regardless the phase of the disease, which increases the risk of cardiovascular complications.

ХОБЛ, бронхиальная астма, артериальная ригидность, индекс аугментации, скорость распространения пульсовой волны, COPD, bronchial asthma, arterial stiffness, augmentation index, pulse wave velocity

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