GENETIC CONTROL OF THE IMMUNE RESPONSE
Abstract
The lecture represents the general concept and structure of major histocompatibility complex (MHC), a molecular structure, localization and main functions of human leukocyte antigen (HLA). It also shows the main mechanism of antigen processing and presentation involving HLA system molecules of classes I and II. The lecture outlines the arguments of existence of polymorphism of HLA system gens on the basis of genetically determined differences which define the high level of individuality of a human organism. Understanding the mechanism of genetic control allows to apply this knowledge in practice not only in the field of transplantation, but also in the field of diagnostic determination of predisposition to various diseases and a personified approach to the treatment of pathological processes.
About the Author
Anna S. Solovyeva
Khabarovsk Branch of the Far Eastern Scientific Center of Physiology and Pathology of Respiration of Siberian Branch RAMS - Research Institute of Maternity and Childhood Protection
Russian Federation
Russian Federation
References
1. Бочков Н.П. Клиническая генетика. М.: Медицина, 1997. 287 с.
2. Бурместер Г.-Р., Пецутто А. Наглядная иммунология: пер. с англ. М.: БИНОМ, 2007. 320 с.
3. Коненков В.И. Медицинская и экологическая иммуногенетика. Новосибирск: СО РАМН, 1999. 250с.
4. Новиков Д.К., Новиков П.Д. Клиническая иммунопатология. Руководство. М.: Мед. лит., 2009. 464с.
5. Ройт А., Бростофф Дж., Мейл Д. Иммунология: пер. с англ. М.: Мир, 2000. 581 с.
6. Тощаков С.В., Доминова И.Н., Патрушев М.В. Технологии высокопараллельного секвенирования в медико-генетических исследованиях // Мед. генетика. 2013. Т.12, №1(127). С.15-25.
7. Хаитов Р.М., Алексеев Л.П. Геномика HLA: новые возможности молекулярной генетики человека в диагностике и терапии // Молекулярная мед. 2003. №1. С.17-31.
8. Tumor necrosis factor-alpha (TNF-alpha) levels and influence of 308-TNF-alpha promoter polymorphism on the responsiveness to infliximab in patient with rheumatoid arthritis/ M.Cuchacovich [et al.] // Scand. J. Rheumatol. 2004. Vol. 33, №4. P.228-232.
9. Dai R., Ahmed S.A. MicroRNA, a new paradigm for understanding immunoregulation, inflammation, and autoimmune diseases // Transl. Res. 2011. Vol.157, №4. P.163-179.
10. Feuk L., Carson A.R., Scherer S.W. Structural variation in the human genome // Nat. Rev. Genet. 2006. Vol.7, №2. P.85-97.
11. Grandi G. Genomics, proteomics and vaccines // England: Wiley&Sons, 2004. 313 р.
12. Cytokine gene polymorphism in human diseases: on-line databases, supplement 2 / N.Haukim [et al.] // Genes Immun. 2002. Vol.3, №6. P.313-330.
13. Influence of vascular endothelial growth factor single nucleotide polymorphism on tumor development in cutaneous malignant melanoma / W.M.Howell [et al.] // Genes Immun. 2002. Vol.3, №4. P.229-232.
14. Population-based case-control study of VEGF gene polymorphisms and breast cancer risk among Chinese women / N.Kataoka [et al.] // Cancer Epidemiol. Biomarcers Prev. 2006. Vol.15, №6. P.1148-1152.
15. Genetic Polymorphism of Vascular Endothelial Growth Factor (VEGFС936T) in the Korean Population / J.K.Kim [et al.] // Korean J. Biol. Sci. 2003. Vol.7, №3. P.261-264.
16. Technological advances in DNA sequence enrichment and sequencing for germline genetic diagnosis / C.S.Ku [et al.] // Expert. Rev. Mol. Diagn. 2012. Vol.12, №2. Р.159-173.
17. Lander E.S. Initial impact of the sequencing of the human genome // Nature. 2011. Vol.470, №7333. P.187-197.
18. Mir K.U. Sequencing Genomes: From Individuals to Populations // Brief. Funct. Genomic. Proteomic. 2009. Vol.8, №5. P.367-378.
19. Reddy P., Negrin R., Hil G.R. Mouse models of bone marrow transplantation // Biol. Blood Marrow Transplant. 2008. Vol.14, №1 (Suppl.1). P.129-135.
20. Reith W., Mach B. The bare lymphocyte syndrome and the regulation of MHC expression // Ann. Rev. Immunol. 2001. Vol.19. Р.331-373.
21. Scifres C., Nelson D. Intrauterine growth restriction, human placental development and trophoblast cell death // J. Physiol. 2009. Vol.587, Pt.14. P.3453-3458.
22. Relative impact of nucleotide and соpy number variation on gene expression phenotypes / B.E.Stranger [et al.] // Science. 2007. Vol.315, №5813. P.848-853.
23. Cytokine gene polymorphism and breast cancer susceptibility and prognosis / K.C.Smith [et al.] // Eur. J. Immunogenet. 2004. Vol.31, №4. P.167-173.
24. Human genes involved in copy number variation: mechanisms of origin, functional effects and implications for diseases / A.J.de Smith [et al.] // Cytogenet. Genome Res. 2008. Vol.123, №1-4. P.17-26.
Review
For citations:
Solovyeva A.S. GENETIC CONTROL OF THE IMMUNE RESPONSE. Bulletin Physiology and Pathology of Respiration. 2014;(51):130-136. (In Russ.)
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