SYNDROMES OF GAS EXCHANGE ABNORMALITIES IN PATIENTS WITH INTERSTITIAL LUNG DISEASES
Abstract
The article presents the analysis of possibilities to identify the causes of pulmonary gas exchange abnormalities in patients with interstitial lung diseases. The parameters of single-breath carbon monoxide diffusing capacity (DL,CO) and body plethysmography were analyzed in 493 patients with interstitial lung diseases. The alveolar volume (VA) was informative for the characteristic of gas-exchanging surface and the calculation of the noncommunicating gas (∆TLC = TLCpleth - TLCHe) was informative for the quantitative estimation of «air trapping». There were determined the four syndromes of specific diffusion disturbances depending on the values of VA and ΔTLC: the syndrome of damage to the alveolar-capillary membrane, the syndrome of «air trapping», the syndrome of gas-exchanging surface reduction and the syndrome of mixed gas exchange abnormalities. The proposed interpretation concept of the data is useful for understanding the causes of gas exchange abnormalities in interstitial lung diseases patients and identification of the individual characteristics of the disease course.
About the Author
Marina Yu. Kameneva
Pavlov First Saint Petersburg State Medical University
Russian Federation
Russian Federation
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Review
For citations:
Kameneva M.Yu. SYNDROMES OF GAS EXCHANGE ABNORMALITIES IN PATIENTS WITH INTERSTITIAL LUNG DISEASES. Bulletin Physiology and Pathology of Respiration. 2015;(56):14-20. (In Russ.)
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