INFLUENCE OF OPTIMIZATION OF ANTIBIOTIC THERAPY ON ACHIEVED REMISSION QUALITY IN SEVERE CHRONIC OBSTRUCTIVE PULMONARY DISEASE

Abstract

The aim of the study was to evaluate the effect of optimization of antimicrobial therapy of exacerbation of severe chronic obstructive pulmonary disease on achieved remission quality. The dynamics of integral indicators (spirographic measures and oxygen saturation) in two groups of clinical follow-up were investigated, in one of which there was antibiotic therapy done on the formulary list against the background of microbiological control (1^st group, n=93), and in another group antibiotic selection was carried out by accident and randomly (2^nd group, n=89). In the 1^st group the differences between the values (Δ) of pulse oxymetry, volumetric and flow indicators of spirogram (SaO₂, FVC, FEV₁, FEV₁/FVC, МEF_25-50-75) were 8.16±0.34; 14.89±0.40; 21.72±0.26; 9.89±0.21; 11.80±0.21; 11.88±0.16; 12.82±0.12, respectively. These changes were more positive and reached the level of statistical significance (р<0.001) compared with the 2^nd group, in which the corresponding indicators were as follows: 4.65±0.34; 9.68±0.34; 16.36±0.26; 4.68±0.18; 5.77±0.14; 6.67±0.17; 6.74±0.18. Optimization of antibiotic therapy is an important factor in quality of remission in severe chronic obstructive pulmonary disease, as evidenced by statistically significant improvement in the leading integrated indicators in lung function.