CHANGES OF HEALTH-RELATED QUALITY OF LIFE IN OVERWEIGHT PATIENTS WITH ASTHMA

Obesity may have a role in the development of asthma, because it is associated with inflammatory processes, including the airway inflammation. The role of overweight in the health-related quality of life (QoL) in asthmatics has not been well described. Aim: to study the influence of obesity on QoL in asthmatics. Methods: 195 patients with mild, moderate and severe asthma were examined. All the patients had standard base therapy with inhalation corticosteroids and beta 2-agonists. The obesity rate (Quetelet index), general (SF-36) and specific (AQLQ) QoL, anxiety and depression rates by Hospital Anxiety and Depression Scale (HADS) were found. Results: Real worsening of QoL by SF-36 questionnaire in overweight patients in comparison with those who have normal body mass by the domens of PF (73.33±2.57 & 62.26±2.58 points, p<0.01), BR (74.04±3.11 & 64.31±3.21 points, p<0.05) and SF (68.55±2.94 & 60.26±2.77 points, p<0.05) was revealed. No significant difference was found out in the groups with overweight and obesity. Sharp drop of rates of general and specific QoL in the group of patients with obesity in comparison with the patients with normal body mass was revealed by domens of PF (73.33±2.57 & 59.56±3.35 points, p<0,001), BR (74.04±3.11 & 61.26±3.81 points, p<0.001) VT (60.47±2.23 & 51.87±3.12 points, p<0.05), SF-36 questionnaire and «General activity» (4.26±0.15 & 3.71±0.16 points) and «Environment» (4.94±0.19 & 3.84±0.38 points, p<0.001) of AQLQ questionnaire. Besides, in the group of patients with obesity the depression rate by HADS grew till the clinically important one (5.50±0.46 and 7.21±0.52 points, respectively). In the general group of respondents reliable correlations of body mass index with anxiety (r=0.16, p<0.05) and depression (r=0.24, p<0.001) were found out. Conclusion: Overweight and obesity lead to the decrease of physical and psychosocial components of QoL in asthmatics and have a negative influence on the rates of anxiety and depression.

бронхиальная астма, качество жизни, избыточная масса тела, ожирение, тревога, депрессия, холодовая гиперреактивность дыхательных путей, контроль болезни, bronchial asthma, health-related quality of life, overweight, obesity, anxiety, depression, cold airway hyperresponsiveness, control of disease

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