Comparative effectiveness of phytoadaptogens in toxic liver damage by carbon tetrachloride
https://doi.org/10.36604/1998-5029-2020-75-97-103
Abstract
Introduction. The study of the possibility of reducing toxic damage to the liver by carbon tetrachloride by the introduction of natural antioxidants is of interest, since the search for antioxidant agents with hepatoprotective activity is an important area of research in experimental pharmacology.
Aim. To study the possibility to correct free radical lipid oxidation of rats’ organism membranes with the introduction of the phytoadaptogens.
Materials and methods. The animals were divided into 5 groups and each of them had 10 rats: intact animals (1) which were held in standard conditions of vivarium; the control group (2) in which rats were given carbon tetrachloride during 3 days daily; the experimental groups (3, 4, 5) in which before the introduction of carbon tetrachloride animals had a daily oral intake of the tincture ginseng, of the tincture schizandra, of the tincture aralia in a dose of 1 ml/kg.
Results. It was found out that in the blood and in the liver of experimental animals the introduction of carbon tetrachloride during 3 days contributes to the increase of lipid hydroperoxides level (by 23 and 43%, respectively), of diene conjugate (by 22 and 39%), and of malonic dialdehyde (by 55 and 79%) against the decrease of antioxidant system activity in the blood of intact animals. The introduction of the phytoadaptogens to rats in the conditions of oxidative stress contributes to the decrease in the blood of lipid hydroperoxides by 13-18%, of diene conjugates by 13-18%, malonic dialdehyde by 19-29% in comparison with the rats of the control group, in the liver by 17-25, 17-24 and 32-39%, respectively. While analyzing the effect of the phytoadaptogens on the activity of the components of antioxidant system it was shown that the level of ceruloplasmin in the blood of animals was higher by 26-41%, of vitamin E by 4-23% in comparison with the same parameters of the rats of the control group, in the liver by 32-74 and 47-57%, respectively.
Conclusion. So, the application of the mentioned phytoadaptogens in the conditions of introduction of carbon tetrachloride in the organism of animals under experiment leads to the stabilization of the processes of peroxidation against the increase of antioxidant system activity.
About the Authors
N. V. SimonovaRussian Federation
Natalia V. Simonova - PhD, D.Sc. (Biol.), Professor of Department of Hospital Therapy with Pharmacology Course.
95 Gor'kogo Str., Blagoveshchensk, 675000
V. A. Dorovskikh
Russian Federation
Vladimir A. Dorovskikh - MD, PhD, D.Sc. (Med.), Professor of Department of Hospital Therapy with Pharmacology Course.
95 Gor'kogo Str., Blagoveshchensk, 675000
R. A. Anokhina
Russian Federation
Raisa А. Аnokhina - MD, PhD (Med.), Senior Lecturer of Department of Hospital Therapy with Pharmacology Course.
95 Gor'kogo Str., Blagoveshchensk, 675000
M. A. Shtarberg
Russian Federation
Mikhail M. Shtarberg - MD, PhD (Med.), Senior Laboratory Assistant of Department of Chemistry.
95 Gor'kogo Str., Blagoveshchensk, 675000
B. V. Kolesov
Russian Federation
Bogdan V. Kolesov - 6rd year Student of Medical Faculty.
95 Gor'kogo Str., Blagoveshchensk, 675000
Ya. E. Gubershtro
Russian Federation
Yana E. Gubershtro - 6rd year Student of Medical Faculty.
95 Gor'kogo Str., Blagoveshchensk, 675000
A. M. Damchat
Russian Federation
Aislana M. Damchat - 6rd year Student of Medical Faculty.
95 Gor'kogo Str., Blagoveshchensk, 675000
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Review
For citations:
Simonova N.V., Dorovskikh V.A., Anokhina R.A., Shtarberg M.A., Kolesov B.V., Gubershtro Ya.E., Damchat A.M. Comparative effectiveness of phytoadaptogens in toxic liver damage by carbon tetrachloride. Bulletin Physiology and Pathology of Respiration. 2020;(75):97-103. (In Russ.) https://doi.org/10.36604/1998-5029-2020-75-97-103