A case of diagnosis of diffuse large b-cell lymphoma with extranodular cervical disease
https://doi.org/10.36604/1998-5029-2021-80-84-90
Abstract
Aim. Demonstration of a case of diagnosing extranodal diffuse large B-cell lymphoma of rare localization – with a massive lesion of the cervix with spread to the body of the uterus and the anterior wall of the vagina.
Results. The patient, born in 1991, considers herself ill since December 2020, when watery, bloody discharge from the genital tract first appeared. She went to the gynecologist at the place of residence; upon examination, a malignant neoplasm was suspected. For further examination and treatment, she was sent to the Amur Regional Oncological Dispensary, where a morphological and immunohistochemical study of the biopsy material was performed. In a histological specimen, there is a picture of lymphoma. Immunohistochemical study: tumor cells express CD10, CD20, BCL6, CD23. Tumor cells do not express CD5 (+ on small T-lymphocytes), BCL2 (+ on small T-lymphocytes), CD30, C-MYC, MUM1. When reacting with Ki-67, 90% of tumor cells are positive. The morphoimmunohistochemical picture is characteristic of diffuse large Bcell lymphoma from cells of germ cell centers.
Conclusion. Diagnosis of extranodal lymphoma can be very difficult, and the leading role belongs to an experienced morphologist and the availability of modern diagnostics of the variant of lymphoma.
About the Authors
A. A. Grigorenko
Amur Regional Oncology Dispensary
Russian Federation
Russian Federation
MD, PhD, DSc (Med.), Professor, Head of Department of Morphology,
110 Oktyabrʹskaya Str., Blagoveshchensk, 675000
V. V. Voytsekhovskiy
Amur State Medical Academy
Russian Federation
Russian Federation
MD, PhD, DSc (Med.), Associate Professor, Head of Department of Hospital Therapy with Pharmacology Course,
95 Gor'kogo Str., Blagoveshchensk, 675000
S. N. Roshchin
Amur Regional Oncology Dispensary
Russian Federation
Russian Federation
MD, PhD (Med.), Morphologist, Department of Morphology,
110 Oktyabrʹskaya Str., Blagoveshchensk, 675000
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Review
For citations:
Grigorenko A.A., Voytsekhovskiy V.V., Roshchin S.N. A case of diagnosis of diffuse large b-cell lymphoma with extranodular cervical disease. Bulletin Physiology and Pathology of Respiration. 2021;(80):84-90. (In Russ.) https://doi.org/10.36604/1998-5029-2021-80-84-90
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