Prostaglandins and their role at early stages of embryonic development (review)
https://doi.org/10.36604/1998-5029-2021-80-129-137
Abstract
Aim. A brief analysis of scientific publications on the role of prostaglandins at early stages of embryonic development has been carried out.
Results. In the process of studying the literature data, both national and, for the most part, foreign authors, the role of prostaglandins was established as paracrine factors involved in an increase in vascular permeability and angiogenesis, mediating the effect of gonads and the expression of growth factors (vascular endothelial growth factor, angiopoietin) during implantation and decidualization. The effects of prostaglandins on the degradation and remodeling of the extracellular matrix of the uterus are described. The role of prostaglandins in the transportation of gametes and embryos is shown. Information on the role of prostaglandins in the growth and development of blastocysts, as well as trophoblast invasion, is presented.
Conclusion. The understanding of the role of prostaglandins at the early stages of embryonic development is far from complete. Despite active research in this direction, scientists still have many questions regarding the mechanisms of action, the functions of prostaglandins at the initial stages of embryogenesis. Most of the information has come from animal studies, mainly rodents. Therefore, to further study the mechanisms underlying the diverse action of prostaglandins on multiple processes of embryogenesis, it is necessary to carry out additional studies in humans.
About the Authors
N. A. Ishutina
Far Eastern Scientific Center of Physiology and Pathology of Respiration
Russian Federation
Russian Federation
PhD, DSc (Biol.), Leading Staff Scientist, Laboratory of Mechanisms of Etiopathogenesis and Recovery Processes of the Respiratory System at Non-Specific Lung Diseases,
22 Kalinina Str., Blagoveshchensk, 675000
I. A. Andrievskaya
Far Eastern Scientific Center of Physiology and Pathology of Respiration
Russian Federation
Russian Federation
PhD, DSc (Biol.), Professor of RAS, Head of Laboratory of Mechanisms of Etiopathogenesis and Recovery Processes of the Respiratory System at Non-Specific Lung Diseases,
22 Kalinina Str., Blagoveshchensk, 675000
References
1. Niringiyumukiza J.D., Cai H., Xiang W. Prostaglandin E2 involvement in mammalian female fertility: ovulation, fertilization, embryo development and early implantation. Reprod. Biol. Endocrinol. 2018; 16(1):43. doi: 10.1186/s12958-018-0359-5
2. Saidova M.A., Yusufi S.D., Rafiyeva Z.Kh., Muhiddinova Z.T. Application of prostaglandins in obstetrics. Vestnik Avitsenny=Avicenna Bulletin 2016; 18(4):83–87 (in Russian). doi: 10.25005/2074-0581-2016-18-4-83-87
3. Samodelkin E.I., Mercucheva N.G., Kosareva P.V., Nesterova L.Y. The role of prostaglandins and cyclooxygenase in pathogenesis of chronic endometritis. Patologicheskaya Fiziologiya i Eksperimental’naya Terapiya (Pathological Physiology and Experimental Therapy) 2017; 61(2):98–100 (in Russian). https://doi.org/10.25557/0031-2991.2017.02.98-100
4. Shirshev S.V. Immunoregulatory effects of fetoplacental complex prostaglandins. Uspekhi sovremennoy biologii 2007; 127(4):358–371 (in Russian).
5. Gu G., Gao Q., Yuan X., Huang L., Ge L. Immunolocalization of adipocytes and prostaglandin E2 and its four receptor proteins EP1, EP2, EP3, and EP4 in the caprine cervix during spontaneous term labor. Biol. Reprod. 2012; 86(5):159, 1–10. doi: 10.1095/biolreprod.111.096040
6. Woodward D.F., Jones R.L., Narumiya S. International Union of Basic and Clinical Pharmacology. LXXXIII: classification of prostanoid receptors, updating 15 years of progress. Pharmacol. Rev. 2011; 63(3):471−538. doi: 10.1124/pr.110.003517
7. Lim H., Gupta R.A., Ma W.G., Paria B.C., Moller D.E., Morrow J.D., DuBois R.N., Trzaskos J.M., Dey S.K. Cyclooxygenase-2-derived prostacyclin mediates embryo implantation in the mouse via PPARdelta. Genes. Dev. 1999; 13(12):1561−1574. doi: 10.1101/gad.13.12.1561
8. Salleh N. Diverse roles of prostaglandins in blastocyst implantation. ScientificWorldJournal 2014; 2014:968141. doi: 10.1155/2014/968141
9. Sugimoto Y., Narumiya S. Prostaglandin E receptors. J. Biol. Chem. 2007; 282(16):11613−11617. doi: 10.1074/jbc.R600038200
10. Israel D.D., Regan J.W. EP3 prostanoid receptor isoforms utilize distinct mechanisms to regulate ERK 1/2 activation. Biochim. Biophys Acta. 2009; 1791(4): 238−245. doi: 10.1016/j.bbalip.2009.01.021
11. Cao J., Nakamura T., Kitazawa T., Yamashiki N., Yamamoto T., Taneike T. Characterization of prostanoid receptors present on adrenergic neurons innervating the porcine uterine longitudinal muscle. Prostaglandins Other Lipid Mediat. 2008; 86(1-4):26−34. doi: 10.1016/j.prostaglandins.2008.02.002
12. Turcotte C., Zarini S., Jean S., Martin C., Murphy R.C., Marsolais D., Laviolette M., Blanchet M.R,. Flamand N. The Endocannabinoid Metabolite Prostaglandin E2 (PGE2)-Glycerol Inhibits Human Neutrophil Functions: Involvement of Its Hydrolysis into PGE2 and EP Receptors. J. Immunol. 2017; 198(8):3255−3263. doi: 10.4049/jimmunol.1601767
13. Harks E.G., Scheenen W.J., Peters P.H., van Zoelen E.J., Theuvenet A.P. Prostaglandin F2 alpha induces unsynchronized intracellular calcium oscillations in monolayers of gap junctionally coupled NRK fibroblasts. Pflugers Arch. 2003; 447(1):78−86. doi: 10.1007/s00424-003-1126-8
14. Cheng L., Kelly R.W., Thong K.J., Hume R., Baird D.T. The effects of mifepristone (RU486) on prostaglandin dehydrogenase in decidual and chorionic tissue in early pregnancy. Hum. Reprod. 1993; 8(5):705−709. doi: 10.1093/oxfordjournals.humrep.a138124
15. von Hof J., Sprekeler N., Schuler G., Boos A., Kowalewski M.P. Uterine and placental expression of HPGD in cows during pregnancy and release of fetal membranes. Prostaglandins Other Lipid Mediat. 2017; 128-129: 17−26. doi: 10.1016/j.prostaglandins.2016.12.003
16. Al-Asmakh M. Reproductive functions of progesterone. Middle East Fertility Society Journal 2007; 12(3):147−150.
17. Nie X., Dai Y., Zheng Y., Bao D., Chen Q., Yin Y., Fu H., Hou D. Establishment of a Mouse Model of Premature Ovarian Failure Using Consecutive Superovulation. Cell. Physiol. Biochem. 2018; 51(5):2341−2358. doi: 10.1159/000495895
18. Bry K., Hallman M. Transforming growth factor-beta 2 prevents preterm delivery induced by interleukin-1 alpha and tumor necrosis factor-alpha in the rabbit. Am. J. Obstet. Gynecol. 1993; 168(4):1318−1322. doi: 10.1016/0002-9378(93)90388-y
19. Cheng L., Kelly R.W., Thong K.J., Hume R., Baird D.T. The effect of mifepristone (RU486) on the immunohistochemical distribution of prostaglandin E and its metabolite in decidual and chorionic tissue in early pregnancy. J. Clin. Endocrinol. Metab. 1993; 77(3):873−877. doi: 10.1210/jcem.77.3.8370712
20. Boshier D.P., Jacobs R.A., Han V.K., Smith W., Riley S.C., Challis J.R. Immunohistochemical localization of prostaglandin H synthase in the sheep placenta from early pregnancy to term. Biol. Reprod. 1991; 45(2):322−327. doi: 10.1095/biolreprod45.2.322
21. Leimert K.B., Verstraeten B.S-E., Messer A., Nemati R., Blackadar K., Fang X., Robertson S.A., Chemtob S., Olson D.M. Cooperative effects of sequential PGF2α and IL-1β on IL-6 and COX-2 expression in human myometrial cells. Biol. Reprod. 2019; 100(5):1370−1385. doi: 10.1093/biolre/ioz029
22. Casey M.L., Korte K., MacDonald P.C. Epidermal growth factor stimulation of prostaglandin E2 biosynthesis in amnion cells. Induction of prostaglandin H2 synthase. J. Biol. Chem. 1988; 263(16):7846−7854.
23. Casey M.L., Cox S.M., Word R.A., MacDonald P.C. Cytokines and infection-induced preterm labour. Reprod. Fertil. Dev. 1990; 2(5):499−509. doi: 10.1071/rd9900499
24. Frazier L.W., Yorio T. Eicosanoids: their function in renal epithelia ion transport. Proc. Soc. Exp. Biol. Med. 1992; 201(3):229−243. doi: 10.3181/00379727-201-43503a
25. Choi Y., Wilson K., Hannon P.R., Rosewell K.L., Brännström M., Akin J.W., Curry T.E. Jr, Jo M. Coordinated Regulation Among Progesterone, Prostaglandins, and EGF-Like Factors in Human Ovulatory Follicles. J. Clin. Endocrinol. Metab. 2017; 102(6):1971−1982. doi: 10.1210/jc.2016-3153
26. Kaczynski P., Baryla M., Goryszewska E., Bauersachs S., Waclawik A. Prostaglandin F2α promotes embryo implantation and development in the pig. Reproduction 2018; 156(5):405−419. doi: 10.1530/REP-18-0225
27. Li X., Ballantyne L.L., Crawford M.C., FitzGerald G.A., Funk C.D. Isoform-Specific Compensation of Cyclooxygenase (Ptgs) Genes during Implantation and Late-Stage Pregnancy. Sci. Rep. 2018; 8(1):12097. doi: 10.1038/s41598-018-30636-x
28. Cella M., Aisemberg J., Sordelli M.S., Billi S., Farina M., Franchi A.M., Ribeiro M.L. Prostaglandins modulate nitric oxide synthase activity early in time in the uterus of estrogenized rat challenged with lipopolysaccharide. Eur. J. Pharmacol. 2006; 534(1-3):218−226. doi: 10.1016/j.ejphar.2006.01.019
29. Mollace V., Muscoli C., Masini E., Cuzzocrea S., Salvemini D. Modulation of prostaglandin biosynthesis by nitric oxide and nitric oxide donors. Pharmacol. Rev. 2005; 57(2):217−252. doi: 10.1124/pr.57.2.1
30. Weems Y.S., Nett T.M., Rispoli L.A., Davis T.L., Johnson D.L., Uchima T., Raney A., Lennon E., Harbert T., Bowers G., Tsutahara N., Randel R.D., Weems C.W. Effects of prostaglandin E and F receptor agonists in vivo on luteal function in ewes. Prostaglandins Other Lipid Mediat. 2010; 92(1-4):67−72. doi: 10.1016/j.prostaglandins.2010.03.004
31. Hristovska A.M., Rasmussen L.E., Hansen P.B., Nielsen S.S., Nüsing R.M., Narumiya S., Vanhoutte P., Skøtt O., Jensen B.L. Prostaglandin E2 induces vascular relaxation by E-prostanoid 4 receptor-mediated activation of endothelial nitric oxide synthase. Hypertension 2007; 50(3):525−530. doi: 10.1161/HYPERTENSIONAHA.107.088948
32. Magness R.R., Shideman C.R., Habermehl D.A., Sullivan J.A., Bird I.M. Endothelial vasodilator production by uterine and systemic arteries. V. Effects of ovariectomy, the ovarian cycle, and pregnancy on prostacyclin synthase expression. Prostaglandins Other Lipid Mediat. 2000; 60(4-6):103−118. doi: 10.1016/s0090-6980(99)00055-6
33. Smith O.P., Battersby S., Sales K.J., Critchley H.O., Jabbour H.N. Prostacyclin receptor up-regulates the expression of angiogenic genes in human endometrium via cross talk with epidermal growth factor Receptor and the extracellular signaling receptor kinase 1/2 pathway. Endocrinology 2006; 147(4):1697−1705. doi: 10.1210/en.2005-1073
34. Al-Sabbagh M., Fusi L., Higham J., Lee Y., Lei K., Hanyaloglu A.C., Lam E.W., Christian M., Brosens J.J. NADPH oxidase-derived reactive oxygen species mediate decidualization of human endometrial stromal cells in response to cyclic AMP signaling. Endocrinology 2011; 152(2):730−740. doi: 10.1210/en.2010-0899
35. Pakrasi P.L., Jain A.K. Cyclooxygenase-2 derived PGE2 and PGI2 play an important role via EP2 and PPARdelta receptors in early steps of oil induced decidualization in mice. Placenta 2008; 29(6):523−530. doi: 10.1016/j.placenta.2008.03.001
36. Callegari E.A., Ferguson-Gottschall S., Gibori G. PGF2alpha induced differential expression of genes involved in turnover of extracellular matrix in rat decidual cells. Reprod. Biol. Endocrinol. 2005; 3:3. doi: 10.1186/1477-7827-3-3
37. Yoshida M., Sagawa N., Itoh H., Yura S., Takemura M., Wada Y., Sato T., Ito A., Fujii S. Prostaglandin F(2alpha), cytokines and cyclic mechanical stretch augment matrix metalloproteinase-1 secretion from cultured human uterine cervical fibroblast cells. Mol. Hum. Reprod. 2002; 8(7):681−687. doi: 10.1093/molehr/8.7.681
38. Slater D.M., Astle S., Woodcock N., Chivers J.E., de Wit N.C., Thornton S., Vatish M., Newton R. Anti-inflammatory and relaxatory effects of prostaglandin E2 in myometrial smooth muscle. Mol. Hum. Reprod. 2006; 12(2):89−97. doi: 10.1093/molehr/gal005
39. Chiossi G., Costantine M.M., Bytautiene E., Kechichian T., Hankins G.D., Sbrana E., Saade G.R., Longo M. The effects of prostaglandin E1 and prostaglandin E2 on in vitro myometrial contractility and uterine structure. Am. J. Perinatol. 2012; 29(8):615−622. doi: 10.1055/s-0032-1311986
40. Ruan Y.C., Zhou W., Chan H.C. Regulation of smooth muscle contraction by the epithelium: role of prostaglandins. Physiology (Bethesda) 2011; 26(3):156−170. doi: 10.1152/physiol.00036.2010
41. Wånggren K., Stavreus-Evers A., Olsson C., Andersson E., Gemzell-Danielsson K. Regulation of muscular contractions in the human Fallopian tube through prostaglandins and progestagens. Hum. Reprod. 2008; 23(10):2359−2368. doi: 10.1093/humrep/den260
42. Huang J.C., Wun W.S., Goldsby J.S., Egan K., FitzGerald G.A., Wu K.K. Prostacyclin receptor signaling and early embryo development in the mouse. Hum. Reprod. 2007; 22(11):2851−2856. doi: 10.1093/humrep/dem304
43. Pakrasi P.L., Jain A.K. Cyclooxygenase-2-derived endogenous prostacyclin reduces apoptosis and enhances embryo viability in mouse. Prostaglandins Leukot. Essent. Fatty Acids 2008; 79(1-2):27−33. doi: 10.1016/j.plefa.2008.07.006
44. Ni H., Sun T., Ma X.H., Yang Z.M. Expression and regulation of cytosolic prostaglandin E synthase in mouse uterus during the peri-implantation period. Biol. Reprod. 2003; 68(3):744−750. doi: 10.1095/biolreprod.102.007328
45. Waclawik A., Kaczynski P., Jabbour H.N. Autocrine and paracrine mechanisms of prostaglandin E₂ action on trophoblast/conceptus cells through the prostaglandin E2 receptor (PTGER2) during implantation. Endocrinology 2013; 154(10):3864−3876. doi: 10.1210/en.2012-2271
46. Horita H., Kuroda E., Hachisuga T., Kashimura M., Yamashita U. Induction of prostaglandin E2 production by leukemia inhibitory factor promotes migration of first trimester extravillous trophoblast cell line, HTR-8/SVneo. Hum. Reprod. 2007; 22(7):1801−1809. doi: 10.1093/humrep/dem125
47. Godbole G., Suman P., Gupta S.K., Modi D. Decidualized endometrial stromal cell derived factors promote trophoblast invasion. Fertil. Steril. 2011; 95(4):1278−1283. doi: 10.1016/j.fertnstert.2010.09.045
Review
For citations:
Ishutina N.A., Andrievskaya I.A. Prostaglandins and their role at early stages of embryonic development (review). Bulletin Physiology and Pathology of Respiration. 2021;(80):129-137. (In Russ.) https://doi.org/10.36604/1998-5029-2021-80-129-137
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