Eicosapentaenoic acid in the peripheral blood of pregnant women in the first trimester with cytomegalovirus infection depending on the specific titre of IgG antibodies to cytomegalovirus

The gas-liquid chromatography method was used to study the content of ω -3 polyunsaturated eicosapentaenoic acid in peripheral blood plasma of first trimester pregnant women with cytomegalovirus infection, depending on the specific titer of IgG antibodies to cytomegalovirus. The study included 135 pregnant women who were divided into groups. A comparison group was in the amount of 45 healthy pregnant women with the physiological course of the first trimester of gestation. The values of the indices studied in this group were used as the starting point of comparison as physiologically normal values. The study group included 90 pregnant women with exacerbation of chronic cytomegalovirus infection in the first trimester, divided into two subgroups, depending on the titer of IgG antibodies to cytomegalovirus: subgroup A (45 women with active cytomegalovirus infection, IgG antibody titer to cytomegalovirus 1:1600); subgroup B (45 women with latent form of cytomegalovirus infection, antibody IgG titer to cytomegalovirus 1:800). Based on the data obtained, it was found out that reactivation of cytomegalovirus infection in the first trimester of gestation leads to the decrease in the concentration of ω -3 polyunsaturated eicosapentaenoic acid in women with peripheral blood plasma by 30% (p<0.001) in subgroup A and by 18% (p<0.01) in subgroup B, in comparison with the similar index of the control group. This dynamics of changes in eicosapentaenoic acid in plasma of peripheral blood of pregnant women with cytomegalovirus infection depends on the specific titer of IgG antibodies to cytomegalovirus and is most pronounced with the active form of cytomegalovirus infection (IgG antibody titer to cytomegalovirus 1:1600). A further study of the level of free polyunsaturated fatty acids of the ω -3 family during pregnancy can allow the development of therapy for the timely correction of perinatal pathology, preventing cell death and improving health outcomes in subsequent life periods of newborns.

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