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MARFAN SYNDROME AS A RISK FACTOR OF A COMPLICATED COURSE OF PULMONARY TUBERCULOSIS

Abstract

Marfan Syndrome (MS) is a hereditary system disease of conjunctive tissue with a wide range of clinical manifestations. At this disease osseous, cardiovascular, respiratory, central nervous systems and eyes are affected. The frequency of respiratory disturbances at MS is from 10 till 25 %. The most frequent pulmonary complication is pneumatothorax conditioned by bullous emphysema. Intensive system and stromal conjunctive tissue changes in the pulmonary tissue, which are revealed through structural and functional rearrangement of lungs parts with ineffective ventilation and perfusion, serve a favorable environment for non-specific and specific (tuberculosis) infection development. Among obtained editions which quite fully describe different aspects of MS there are almost no woks about the correlation between MS and pulmonary tuberculosis. This is probably because of the fact that the staff of TB dispensaries are not informed enough about MS which is potentially dangerous both for tuberculosis development and as the one able to complicate its clinical course.
The personal clinical observation of tuberculosis pulmonary damage against MS has been given. Modern high technologies methods have been applied for X-ray diagnostics. The dynamics of tuberculosis course has been studied.

About the Authors

Anatoliy V. Lenshin
Far Eastern Scientific Center of Physiology and Pathology of Respiration SB RAMS
Russian Federation


Andrey V. Il'in
Far Eastern Scientific Center of Physiology and Pathology of Respiration SB RAMS
Russian Federation


Tat'yana A. Mal'tseva
Far Eastern Scientific Center of Physiology and Pathology of Respiration SB RAMS
Russian Federation


Lora Yu. Tikhonova
Amur Regional Antitubercular Dispensary
Russian Federation


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Review

For citations:

Lenshin A.V., Il'in A.V., Mal'tseva T.A., Tikhonova L.Yu. MARFAN SYNDROME AS A RISK FACTOR OF A COMPLICATED COURSE OF PULMONARY TUBERCULOSIS. Bulletin Physiology and Pathology of Respiration. 2012;(44):137-144.

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