INTERLEUKIN 15 AND ITS ROLE IN IMMUNE INFLAMMATION
Abstract
Since the cloning of interleukin-15, a number of clinical studies on molecular structure of this cytokine has been done. An important feature of interleukin-15 is its structural and functional similarity with interleukin-2, but the specificity of interleukin-15 is provided with its own unique receptor α-chain. The review presents recent data on the molecular structure, mechanism of action and biological effects of interleukin-15, the role of this cytokine in the development of the disease and its potential clinical significance as a therapeutic agent.
About the Authors
Elena A. Sobko
Krasnoyarsk State Medical University; Krasnoyarsk Regional Clinical Hospital
Russian Federation
Russian Federation
Irina A. Solovʹeva
Krasnoyarsk State Medical University
Russian Federation
Russian Federation
Irina V. Demko
Krasnoyarsk State Medical University
Russian Federation
Russian Federation
Angelina Yu. Kraposhina
Krasnoyarsk State Medical University
Russian Federation
Russian Federation
Natalia V. Gordeeva
Krasnoyarsk State Medical University; Krasnoyarsk Regional Clinical Hospital
Russian Federation
Russian Federation
Svetlana V. Chubarova
Krasnoyarsk State Medical University; Krasnoyarsk Regional Clinical Hospital
Russian Federation
Russian Federation
Ol'ga P. Ishenko
Krasnoyarsk State Medical University; Krasnoyarsk Regional Clinical Hospital
Russian Federation
Russian Federation
Stepan A. Egorov
Krasnoyarsk State Medical University
Russian Federation
Russian Federation
Aysuluu S. Bazarova
Krasnoyarsk State Medical University
Russian Federation
Russian Federation
Svetlana S. Vturina
Krasnoyarsk State Medical University
Russian Federation
Russian Federation
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Review
For citations:
Sobko E.A., Solovʹeva I.A., Demko I.V., Kraposhina A.Yu., Gordeeva N.V., Chubarova S.V., Ishenko O.P., Egorov S.A., Bazarova A.S., Vturina S.S. INTERLEUKIN 15 AND ITS ROLE IN IMMUNE INFLAMMATION. Bulletin Physiology and Pathology of Respiration. 2015;(57):113-119. (In Russ.)
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