The examination of 98 patients with bronchial asthma and 10 practically healthy volunteers was done. The dynamics of oxidative stress parameters in the exhaled breath condensate and the blood serum in dependence on the severity degree of a disease and the level of asthma control was studied. It was established that patients with bronchial asthma had much higher concentration of Н₂О₂ in the exhaled breath condensate than in the healthy persons, which closely correlates with the bronchi patency. Alongside with the growth of the disease severity degree, the increase of diene conjugates of Н₂О₂ in the exhaled breath condensate as well as malonic dialdehyde in the blood serum was found out. Not depending on the severity degree as soon as the control over asthma was lost, patients had the growth of Н₂О₂ concentration in the exhaled breath condensate and of malonic dialdehyde in the blood serum as well as the decrease of endogenous vitamin E.

86 patients with bronchial asthma were examined. Clinical and immunological differences among patients with and without cold airway hyperresponsiveness were studied. It is shown that patients with cold airway hyperresponsiveness have more severe allergic reactions and immune disorders.

135 patients with pneumonia caused by highly pathogenic influenza A(H1N1) were examined. 58 patients were admitted to the intensive care units. 40 indices determined in all the patients in the first days of hospitalization were included into the multi-factor regression model. It was shown that independent prognostically unfavorable criteria were the development of acute respiratory distress-syndrome, the rise of the level of creatine phosphokinase, leukocytes and desquamative endothelial cells of blood. Of medications the prediction was authentically affected by zanamivir and oseltamivir, prescribed in due time.

The results of the research of right heart and pulmonary hemodynamics features in 136 patients with chronic obstructive pulmonary disease of II-III stages combined with stable angina of II-III functional class and in 56 patients at isolated chronic obstructive pulmonary disease of II-III stage are given in the article. It is established that structural and functional reorganization of right heart and the change of pulmonary hemodynamic at joint course of chronic obstructive pulmonary disease and ischemic heart disease in comparison with isolated chronic obstructive pulmonary disease advances «one step» forward, which is accompanied by increase in frequency of hypertrophy and dilatation of right heart and restrictive and «pseudo-normal» types of diastolic dysfunction of the right ventricle.

45 patients with bronchial asthma and uncontrolled course of the disease went through echocardiography. The geometry of the right ventricle on its different levels (inflow and outflow) was studied. It was established that patients with a mild bronchial asthma against the absence of pharmacotherapeutic control had an increase of transverse diameter and square of the right ventricle combined with the decrease of the fraction of square change in the top, which proves the forming of structural and functional changes of the right ventricle at the given stage of the disease development. Bronchial asthma severity degree growth leads to more intensive remodeling of the right ventricle and to changes of regional indices of reduction at inflow level.

124 patients with bronchial asthma were studied on the elastic properties of arterial vessels by volume sphygmography depending on the severity of the disease. It was found out that in patients with asthma in comparison with healthy people the processes of remodeling of arterial channel had mainly the increase of rigidity of main arteries of elastic type which was proved by the rise of values of basic parameters that reflect vessel stiffness - carotid-femoral velocity of a pulse wave, the index of augmentation, right/left heart malleolar vessel index. The acceleration of pulse wave velocity by main arteries of the elastic type in patients with bronchial asthma was combined with the rise of augmentation index, which proves more significant functional activity of endothelium at the growth of asthma severity.

To estimate the influence of chronic obstructive pulmonary disease on hemostasis and endothelium function in old people with chronic heart failure of ischemic genesis 158 patients with ischemic heart disease and signs of chronic heart failure of II-III functional classes were examined. According to the results of spirography with bronchodilatation test among patients with ischemic heart disease two groups were formed: the one included those people who had obstructive pulmonary disease, the other one had those who did not have it. An endothelium function was estimated in all patients by the increase of brachial artery diameter at the test with reactive hyperemia, by the level of nitric oxide and parameters of hemostasiogram. It was found out that the changes in hemostasis in patients of both groups revealed themselves through chronic hypercoagulation syndrome that was more evident in patients with chronic pulmonary disease. An evident endothelium dysfunction was in the patients of both groups. Chronic obstructive pulmonary disease did not have a big influence on the parameters of endothelium-dependent vasodilatation of brachial artery in old patients with ischemic heart disease and chronic heart failure of II-III functional classes.

The estimation of efficacy of long pathogenetic therapy with tiotropium bromide was done among 62 patients with chronic obstructive pulmonary disease of the second stage. It was conducted by a general practitioner on an outpatient basis during 18 months. The dynamics of changes of clinic symptomatology, short breath severity degree by MRC scale, general and specific quality of life, FEV₁ and echocardiogram was studied. As a result of long-term treatment patients had a significant decrease of clinical symptoms intensity, short breath severity degree and bronchial obstruction; the parameters of intracardial hemodynamics, general and specific parameters of quality of life improved, which proves the efficacy of the mentioned therapy in real daily clinical practice.

Epidemiologic researches about the study of respiratory allergy and atopic dermatitis spread in 1512 pupils of Yakutsk living in different ecological conditions were done. Children from areas with ecologically unfavorable conditions had a higher frequency of bronchial asthma symptoms, allergic rhinitis and atopic dermatitis during the last year. It outnumbered the morbidity rate of children from more favorable ecological areas in 2.4, 2.8 and 2.1 times, respectively. Children from ecologically unfavorable area had more frequent attacks of bronchial asthma, insomnia, speech disability, dry cough at nights; children with allergic rhinitis had evident disturbances of daily activity, high frequency of pollinosis, which proved the tendency of allergic diseases to develop more complicated clinical course in ecologically unfavorable areas.

The description of the developed universal system of remote wireless monitoring of respiratory noises of a person and apnoea diagnostics are given in the article. The basic characteristics of the device and software as well as the algorithm of application are presented.

Cytological and morphometric study of nasal secret and saliva was done in 117 healthy people. It was found out that cytological and morphometric parameters of upper airways secret and morphological parameters of mouth microbiocenosis can serve as a marker of environment cold temperatures influence on the body of a man and as an evaluative criterion of dihydroquertecin bioflavonoid effectiveness at the correction of cold adaptation on the body of a man. At the discriminant analysis a high informativeness of the partial weight of cells of epithelium in nasal cytogram was found.

114 pregnant women with disorders of menstrual function formation at puberty and 30 women without disorders of menstrual function formation were examined. It was established that pregnancy in women with disorders of menstrual function formation at puberty was often complicated with primary and chronic placental insufficiency, the threat of miscarriage, iron-deficiency anemia in comparison with women without disturbances of reproduction system recovery. With the aim of prediction chronic placental insufficiency development, discriminant equations were offered. They cover the character of menstrual function disturbance at puberty in dependence on the content of progesterone, β-subunit of chorionic gonadotropin and echographic measure of the distance from the lower part of placenta till the internal gullet.

Due to immunodeficiency at exacerbation of herpes-virus infection pathological changes in adrenal glands, liver and the lungs of the fetus are observed. The formation of placental hormones is broken. An embryon or fetus die.

The structure of ω-3 polyunsaturated fatty acids in lipids of membranes of placentas in parturient women who suffered herpes-virus infection exacerbation during pregnancy has been examined. The decrease of concentration of essential eicosapentaenoic and docosahexaenoic acids in the structure of lipids of the placenta at high antibody titer IgG to a virus of simple herpes was found out; this may lead to disturbance of high-energy products to the umbilical blood of the fetus.

30 umbilical cords from almost healthy women were studied with histochemical methods at 8-14 weeks of gestation. It was found out that at the formation of the vessels of the umbilical cord in endothelium and adjoining muscle elements at early stages of gestation there is a high activity of succinate dehydrogenase, arginin dehydrogenase and NO-synthase. Mesenchymal cells have high contents of neutral polysaccharides and glycosaminoglycans.

To form adequate state policy that aims at the increase of efficacy of treatment and prophylactics in respiratory health protection, the estimation of social and economic burden of the state and society was done. The burden is caused by temporary disability provoked by respiratory diseases on the territory of the Amur region, which leads to the drop of the volume of gross regional output.

Practical recommendations about improvement of diagnostics service organization in the Amur region and regional clinical hospital were developed by results of the comparative analysis of activity of regional clinical hospitals with various forms of counseling and diagnostics care organization (the Amur regional clinical hospital, the Voronezh regional clinical hospital, the Kemerovo regional clinical hospital), by results of sociological studying of doctors and patients opinion about availability, quality and state of counseling and diagnostics care organization, by the state of material base of diagnostics divisions of regional hospitals. Studying the experience of counseling and diagnostics centers founding in our country in leading treatment and prophylaxis institutions of the region proves that this organizational form is the most perspective direction of development and improvement of counseling and diagnostics medical care.

The article deals with the technique of development and arrangement of new medical technologies in the Far-eastern scientific center of physiology and pathology of respiration SB RAMS. A three-level system that includes the author, the tutor and the head of the scientific laboratory is described. The stages of filling in the forms and new medical technologies obtained by the center are presented.

The dynamics of the general and primary morbidity of myopia (shortsightedness) in the Amur region over the past 20 years is given in the research. The data in dependence on belonging of people with myopia to different age groups (children, teenagers, adults) are listed. It is established that highest possible figures of specific gravity and myopia morbidity occur in the age group of teenagers. General myopia morbidity among people of the Amur region steadily grows as well as constant primary morbidity of this pathology. At the same time there is a clear tendency to the decrease of specific gravity of myopia among other disease of eyes and its appendages.

It is established that in the air of closed premises besides cultivated rudiments of bacteria and microscopic fungi, lifeless threads of fungi and various variants of L-forms (plural elementary bodies, cylindrical and threadlike bacterial structures) circulate. The extract of Viscum сoloratum of 10 ml is offered to be added in simple nutrient agarinic media as an additional component or complete replace of distilled or waterpipe water. This updating raises the diagnostic efficacy of simple agarinic media and the output of colonies during the process of bacteria and fungi sedimentation from the air of closed premises.

The ability to perceive temperature provides the basis for adaptive responses aimed at the active elimination of the threat or of the disturbance in temperature homeostasis. During last decades some members of transient receptor potential (TRP) cation channels family have been identified as thermoreceptors. Recent studies indicate their possible involvement in a number of physiological processes and pathological states. Moreover, it has been confirmed by now that thermosensitive TRP channels are capable to mediate certain respiratory responses. This review contains modern data on genetics, molecular structure and regulation of TRPM8-the ion channel activated by cold temperatures.

This paper presents a modern view on etiology and pathogenesis of hypothalamus dysfunction from the antenatal period. There are variations of disorders in hypothalamic-pituitary-ovarian-adrenal system given in the paper. Adipose tissue is considered as a separate autocrine-endocrine organ. A modern mechanism of pathogenesis of hypothalamus dysfunction is shown against the background of the formation of metabolic disorders, insulin resistance, thrombophilia and endotheliopathy.

Modern conceptions about the reasons of initial open angle glaucoma development are given in the review. The questions of theories of development and progression of glaucomatous optic neuropathy as a principal cause of irreversible blindness are discussed. The data about the opportunity of bloodsuckers treatment application in complex treatment of patients with initial open angle glaucoma are given.