TRPM8 GENE POLYMORPHISM AND SMOKING AS THE FACTORS OF SEVERE BRONCHIAL OBSTRUCTION IN PATIENTS WITH ASTHMA
https://doi.org/10.12737/article_59acaae9dad902.64338769
Abstract
The aim of the study was to determine the role of rs11562975 polymorphism of TRPM8 gene and tobacco smoking in the formation of severe bronchial obstruction in asthma patients. According to this aim, 416 patients with varying severity of asthma were examined. The study design included standard spirometry, genotyping of rs11562975 TRPM8 gene polymorphism and evaluation of the status and duration of smoking. The study revealed the detrimental effect of smoking on the respiratory function in patients with a pack/year index ≥10. rs11562975 polymorphism had a modulating effect on the smoking in patients with asthma. The influence of smoking ≥10 packs-years on the formation of severe bronchial obstruction was more pronounced among carriers of GC genotype, compared to patients with GG genotype. In case of pack-year history ≥20, the GC genotype significantly increased the risk of severe bronchial obstruction in the examined patients.
About the Authors
D. A. Gassan
Far Eastern Scientific Center of Physiology and Pathology of Respiration
Russian Federation
Russian Federation
D. E. Naumov
Far Eastern Scientific Center of Physiology and Pathology of Respiration
Russian Federation
Russian Federation
O. O. Kotova
Far Eastern Scientific Center of Physiology and Pathology of Respiration
Russian Federation
Russian Federation
А. G. Prikhodko
Far Eastern Scientific Center of Physiology and Pathology of Respiration
Russian Federation
Russian Federation
V. P. Kolosov
Far Eastern Scientific Center of Physiology and Pathology of Respiration
Russian Federation
Russian Federation
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Review
For citations:
Gassan D.A., Naumov D.E., Kotova O.O., Prikhodko А.G., Kolosov V.P. TRPM8 GENE POLYMORPHISM AND SMOKING AS THE FACTORS OF SEVERE BRONCHIAL OBSTRUCTION IN PATIENTS WITH ASTHMA . Bulletin Physiology and Pathology of Respiration. 2017;(65):24-30. (In Russ.) https://doi.org/10.12737/article_59acaae9dad902.64338769
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