To study clinical-functional features of formation of osmotic airway hyperresponsiveness, a complex examination of 59 patients with bronchial asthma was done. The study included the detailed interviewing, objective examination to diagnose the severity of the disease and the features of its course, questionnaire to estimate the clinical signs of osmotic airway hyperresponsiveness, the study of lung ventilation function by the spirometry, bronchial challenge tests with the inhalation of distilled water (DWI), NaCl 4.5% solution, dosed exercise test (DET). According to the anamnestic testing, after the change of air humidity the patients had asthma attack in 14% of cases, shortness of breath (54%) combined with increased dyspnea (32%), cough (39%), in some cases hoarseness, nasal blockage (19%), in 34% of cases the patients needed the additional intake of bronchodilator to stop an attack. After the challenge with DWI the symptoms of airway irritation were in 61%, after hypertonic solution inhalation (HSI) they were in 63%; in 13% of patients they were after DET and basically resembled the feelings obtained under amnestic testing. The significant drop of FEV₁ after DWI was registered in 37% of patients (ΔFEV₁=-18.1±2.50%), after HIS it was in 29% (ΔFEV₁=-17.8±1.87%), after DET it was in 18% (ΔFEV₁=-18.9±3.30%). It was found out that neither of the patients responded to all the challenges by simultaneously equal decrease of parameters of bronchial conductance, but there were coincidences in the responses to hypo- and hyperosmolar stimuli introduced in the form of aerosol. The patients who had a positive response to DWI in 58% had an intensive bronchial response to HIS and in 13% they had a positive response to DET. During the study it was revealed that in more than 30% of patients with bronchial asthma there were responses to osmotic stimuli and in 58% there is oversensitivity to the combined effect of osmotic stimuli.

The article presents the analysis of possibilities to identify the causes of pulmonary gas exchange abnormalities in patients with interstitial lung diseases. The parameters of single-breath carbon monoxide diffusing capacity (DL,CO) and body plethysmography were analyzed in 493 patients with interstitial lung diseases. The alveolar volume (VA) was informative for the characteristic of gas-exchanging surface and the calculation of the noncommunicating gas (∆TLC = TLC_pleth - TLC_He) was informative for the quantitative estimation of «air trapping». There were determined the four syndromes of specific diffusion disturbances depending on the values of VA and ΔTLC: the syndrome of damage to the alveolar-capillary membrane, the syndrome of «air trapping», the syndrome of gas-exchanging surface reduction and the syndrome of mixed gas exchange abnormalities. The proposed interpretation concept of the data is useful for understanding the causes of gas exchange abnormalities in interstitial lung diseases patients and identification of the individual characteristics of the disease course.

The paper presents the analysis of basic therapy principles compliance with the National Programme «Bronchial Asthma in Children. Strategy of Therapy and Prevention» (2008) and its efficacy in children with different forms of bronchial asthma during 2008-2012. 312 case histories of children aged 1 to 16 years old with asthma, including 139 patients with mild, 98 with moderate and 75 with severe asthma were analyzed. The symptoms of the disease are presented by clinical index, the dynamics of functional parameters is reflected through the difference of average daily bronchial patency at the beginning and end of treatment. It was found out that chronologically by 2011 there was a tendency to use a «step-down» approach and cromones substitution for inhaled corticosteroids for the mild form of the disease both in hospital and outpatient settings. In comparison with the medications made of cromoglicic acid, the base therapy with inhaled glucocorticoids in the acute stage of the disease contributes to a statistically significant reduction of cough, shortness of breath, recovery of lung function in average by 66% over a short period of time.

The aim of the study was to evaluate the effect of optimization of antimicrobial therapy of exacerbation of severe chronic obstructive pulmonary disease on achieved remission quality. The dynamics of integral indicators (spirographic measures and oxygen saturation) in two groups of clinical follow-up were investigated, in one of which there was antibiotic therapy done on the formulary list against the background of microbiological control (1^st group, n=93), and in another group antibiotic selection was carried out by accident and randomly (2^nd group, n=89). In the 1^st group the differences between the values (Δ) of pulse oxymetry, volumetric and flow indicators of spirogram (SaO₂, FVC, FEV₁, FEV₁/FVC, МEF_25-50-75) were 8.16±0.34; 14.89±0.40; 21.72±0.26; 9.89±0.21; 11.80±0.21; 11.88±0.16; 12.82±0.12, respectively. These changes were more positive and reached the level of statistical significance (р<0.001) compared with the 2^nd group, in which the corresponding indicators were as follows: 4.65±0.34; 9.68±0.34; 16.36±0.26; 4.68±0.18; 5.77±0.14; 6.67±0.17; 6.74±0.18. Optimization of antibiotic therapy is an important factor in quality of remission in severe chronic obstructive pulmonary disease, as evidenced by statistically significant improvement in the leading integrated indicators in lung function.

Using flow cytometry the spectrum and prevalence of sensitization to beta-lactam antibiotics in 76 patients with bronchial asthma of allergic, not allergic and mixed type were estimated and the frequency of cross-responses to penicillin was found out. In 38 patients at the time of the study moderate bronchial asthma was diagnosed and in 38 patients there was a severe course of the disease. Dosage history intolerance was observed in patients with mixed and allergic type of the disease. It was shown that the sensitization of patients with asthma was significantly higher (p<0.05) than in healthy people in the control group and was identified for penicillins, cephalosporins of I and II generation and carbapenems. Significantly more frequent it was in the group with mixed asthma (р<0.05). Sensitization to penicillin was found in 12 patients with bronchial asthma. Three patients were identified to have monosensibilization to penicillin, and 9 patients had besides penicillin sensitization to other groups of beta-lactam antibiotics. Cross reactions of penicillin with carbapenems (50%) and with cephalosporins of I generation (25%) were identified most often.

The aim of the research is to evaluate clinical and economic reasonableness in using mineral water for treating patients with acute suppurative rhinosinusitis. There were 98 patients with acute suppurative rhinosinusitis under examination (47 women, 51 men, the average age was 38.8±9.8 years). The first group consisted of 48 patients who got antibacterial, desensitization therapy, the puncture of maxillary sinuses with the introduction of cefazolin solution; the second group consisted of 50 patients, who got basic medicament treatment together with the puncture of maxillary sinuses and introduction of mineral water Talaya (Magadan region) and further endonasal electrophoresis with mineral water by the developed methods. Clinical efficiency was evaluated by dynamics of clinical, laboratory and roentgenological data, state of transport function of nose mucous membrane. The integral index of overall state of the patient was calculated; there was interviewing to estimate the results of the treatment. The economic analysis was done by the method of expenses minimization considering government territorial programme that guarantees free medical care to citizens. During complex treatment with mineral water the duration of pyretic temperature, difficulty in nasal breathing, nasal purulent secretion, maxillary sinuses pains decreased. The integral index of clinical efficiency showed faster relief of clinic and laboratory symptoms of patients from the second group. The quantity of invasive procedures decreased, and patient’s satisfaction of treatment increased. The cost of treatment in the groups differed because of the decrease of duration for in-patient treatment in the second group to 8.77±0.23 days (in the first group - 10.39±0.56 days, р<0.05). Direct expenses decreased by 4.7%. The research showed that complex treatment of patients with acute suppurative rhinosinusitis using mineral water Talaya for elimination therapy and endonasal electrophoresis helps to eliminate clinical symptoms of the disease, decrease the duration of in-patient treatment, lower the cost of treatment and improve the comfort of therapeutic measures.

To develop and justify the method of prediction of rhinosinusitis polyposa development 42 patients with bronchial asthma and rhinosinusitis polyposa (polyposa tissue was first identified under rhinoscopy study) and 68 patients with asthma without rhinosinusitis polyposa were examined. All the participants of the research were studied upon endotoxemia indicators: the number of leucocytes, mean mass molecules, creatinine, urea and erythrocyte sedimentation rate. Using these indicators, to predict the development of rhinosinusitis polyposa development in asthmatics the equation by discriminant analysis was established: D = 6.900 × leucocytes (×10⁹/l) + 2.640 × erythrocyte sedimentation rate (mm/h) + 17.819 × mean mass molecules (optical density units) + 1.127 × creatinine (mkmole/l) + 24.801 × urea (mmole/l) , where D is a discriminant function with borderline values of 223.12. If D is more or equal to the borderline value in asthma patients the development of rhinosinusitis polyposa is predicted; if D is less than the values of the discriminant function than there is no rhinosinusitis polyposa. The probability of the correct prediction gives a chance to predict the development of rhinosinusitis polyposa in asthma patients at early stages.

The aim of the research is the study of genotoxic effects of oxidative stress in elderly patients with stable chronic obstructive pulmonary disease (COPD). The levels of malondialdehyde (MDA), total antioxidant activity (TAA) and 8-hydroxydeoxyguanosine (8-ОНdG) were studied in the blood of somatically healthy persons and middle-aged and elderly COPD patients. The age-dependent 27% increase in oxidative DNA damage marker was found for somatically healthy people (р<0.05). The hyperoxidation and the suppression of antioxidant defense were revealed for mature patients with COPD (67% MDA increase, р<0.001; 25% TАА decrease, р<0.01); it was followed by 126% increase in MDA/TAA ratio (p<0.001). In elderly patients with COPD the levels of MDA were comparable with control group, with 26% decrease in TAA levels (p<0.05). The peroxidation coefficient MDA/TAA was 46% higher than that of the control group (р<0.01), which indicates the shift in balance towards prooxidant processes. The 8-ОНdG levels were 15% higher for elderly patients in comparison with healthy patients of the same age (р<0.05). The intensity of oxidative genome damage also was 97% higher for middle-aged (p<0.001) and 82% for elderly patients (p<0.001) in comparison to healthy people of the same age. Thus, oxidative stress accompanies COPD in middle-aged and elderly patients and causes oxidative DNA damage. The genotoxic effect is most pronounced in elderly patients with COPD, which may be due to the age-dependent suppression of activity of antioxidant ferments, the reduction in DNA repair activity or may indicate the adaptive reorganization of genome. The study of genotoxic effects of oxidative stress in COPD patients considering the age allows to identify molecular pathogenetic mechanisms and develop prevention methods for correction.

Multivariate analysis of parameters of long-term prevention of disorders of cardio-pulmonary hemodynamics was done in non-residents of the North with moderate-to-severe chronic obstructive pulmonary disease (COPD) with comorbid state (CS). During 10 years clinical manifestations and echocardiography (ECHOCG) indicators were estimated. 46 patients with COPD and CS who had complex rehabilitation program and 39 patients of the control group who had a traditional health survey were examined. It was found out that the patients of the main group unlike the control group by the end of the observation had ECHOCG indicators maximally close to the level of healthy people or back to normal, which agreed with the improvement of diastolic function of left ventricle (LV) and right ventricle (RV). The measure of the ratio of the maximum rates of early and late ventricular filling (Е/А) was improved: Е/А LV=1.18±0.02 and Е/А RV=1.16±0.01, in the control group the values were 0.75±0.07 and 0.71±0.02 (р<0.001), respectively. In the patients of the main group there was a significant decrease of general volume (vX) from 1.12999848E0011 till 198349.2400 and the general indicator of asymmetry (rX) from 50.3595 till 16.2300, which shows the decrease of chaotic dynamics of ECHOCG parameters, stable state of the functional system and the positive therapeutic effect of the improved program of treatment of patients of the main group. In the main group there was a significant decrease of development of chronic cardiac failure (2.9 times less), myocardial infarction (16 times less), cerebral stroke (2.4 times less), severe arrhythmia (2.4 times less), and the part of patients of II and III group of disability was as little as 2.2 times.

The range and detection rate of respiratory viruses at the onset of community-acquired pneumonias were studied in 276 children at the age of 3 months - 16 years old in epidemic seasons of 2012-2013 and 2013-2014 by the PCR method. The etiology of respiratory infection was identified in 51.2%-59.3% of the children examined. In February-March of 2013 the children were revealed to have А(H1N1)pdm and А(H3N2) influenza viruses. In February-April of 2014, three influenza viruses were detected, namely: А(H1N1)pdm, А(H3N2) and B influenza viruses. The rate and interval of pandemic А(H1N1)pdm influenza virus detection in 2012-2014 was found to decrease as compared with the 2010-2011 season. A share of a particular agent in the etiological structure of acute respiratory viral infections (ARVI) depends on the year, season and children’s age. Rhinoviruses were most common and were detected at a rate of 6-70% in all age groups with two seasonal peaks of maximum detection in autumn and spring. Adenoviruses were detected in autumn and winter seasons, RS-virus and hMPV - in winter and spring seasons. Bocaviruses were only found in autumn and winter in children under 3 years old. Coronaviruses were never detected. The application of PCR method contributes to quick etiologic ARVI diagnose, the correct estimation of epidemiologic situation; it also allows to improve epidemiologic supervision over acute respiratory diseases.

The analysis of the levels of metabolites of vitamin D (1.25-dihydroxyvitamin D) and the level of α-defensins 1-3 in serum was done to assess the efficacy of cholecalciferol (vitamin D3) in children with recurrent diseases of the respiratory system. The study included 103 children, 89 of whom were from the group of frequent recurrent respiratory diseases. The frequency of acute respiratory infections more than 8 times a year became the criterion for inclusion of children in the group. The children with recurrent diseases were divided into two groups: the first group (control), where 38 children took vitamin D₃, and the second group (comparison), where 30 children did not get vitamin D₃. The third group included 35 almost healthy children. Vitamin D was used in children in the control group by 1 drop (500 IU) 1 time per day during the period of adaptation to school (3 months). At the end of the study it was revealed that there was statistically reliable (р=0.05) reduction in the concentration of 1.25-dihydroxyvitamin D in the control group (126.8±12.6 pmol/l) and in the comparison group (110.5±3.7 pmol/l) as compared with healthy children (169.0±48.1 pmol/l). The concentration of α-defensins 1-3 in the serum of the control group (258.2±35.0 pg/ml) and the comparison group (222.2±37.3 pg/ml) was 2 and 1.7 times higher (p=0.05), respectively, than in healthy children (127.2±45.70 pg/ml). After 3 months the concentration of vitamin D metabolites in the control group was 1.5 times higher (239.8±10.5 pmol/l) compared with healthy children. The reduction of the incidence of respiratory diseases in children of the control group was accompanied by 2.4 times decrease of α-defensins 1-3 in the serum (105.9±35.0 pg/ml). Taking into account the data obtained, the possible cause of frequent respiratory diseases in children can be the lack of metabolites of vitamin D. The intake of cholecalciferol showed 1.8 times increase of 1.25-dihydroxyvitamin D and 2.4 times reduction of α-defensins 1-3, 2 times reduction in the incidence of respiratory infections.

The aim of the research was to assess the bronchial patency in infants with bronchial dysplasia with the help of bronchophonography. The data of bronchophonograms of 88 patients diagnosed with bronchopulmonary dysplasia and 30 infants without any respiratory pathology were studied. The main group was divided into 2 subgroups: A group included 22 infants with the classic form of a disease; B group had 66 infants with a new form of bronchopulmonary dysplasia. It was found out that infants with bronchopulmonary dysplasia had increased indicators of the acoustic work of breathing in all frequency diapasons and increased coefficients, which proves the disturbance of the respiratory function in all parts of bronchi. In the infants with the new form, the indicators of the acoustic work of breathing in the low and mid frequency diapason did not differ from the indicators of infants with the classic form, but the indicators in the high frequency diapason were 1.2 times lower than at classical bronchopulmonary dysplasia and the coefficients were 2 times higher. These changes show less expressed obstructive changes at the new form of bronchopulmonary dysplasia in comparison with the classical one. At bronchopulmonary dysplasia of moderate and severe degree there is the disturbance of bronchial patency in all parts of bronchi. Under the new form large bronchi are predominantly damaged. Standard medical therapy leads to the decrease of indicators of acoustic work of breathing in all frequency diapasons. Thus, bronchophonography can be applied for identification of bronchial patency and the severity degree of bronchopulmonary patency and estimation of efficacy of the therapy in infants.

In this paper the results of granulometric research of particles from the atmospheric suspensions of the snow collected in 5 points of the Nakhodka city district (Primorsky Krai) in the winter of 2012-2013 including a sanitary protection zone of the coal terminal of Vostochny port are given. In all points of selection in the areas close to the coal terminal the concentration of microdimensional particles from 8 to 65% is noted. The surface area of these particles reaches 7312.63 cm²/cm³. The material analysis of particles of snow cover in the studied zones of the Nakhodka city district showed the pollution of the atmosphere with microparticles of coal, metals and rare-earth elements, which proves negative influence of the open coal terminal on the nearby settlement.

In order to study the peculiarities of socio-economic status of pregnant women with asthma of various severity, 365 cases have been examined during three periods of 1995-2002, 2002-2008 and 2009-2014. Social characteristics that have been analyzed for the last 18 years include age, social and marital status, financial status of the family, parity, complicated obstetric history, habitual intoxication and its impact on the course of asthma in pregnant women. The results show that the ratio of pregnant women with asthma has risen. Due to the high urbanization of the population, an increasing number of women consider their career the most important, which increases the percentage of nulliparous in older age, affecting both the course of asthma and that of the pregnancy. There is a growing influence of social factors such as lack of material support, marital status which inhibit the positive mood to have healthy pregnancy. Also, despite all the government measures to limit tobacco use, a large percentage of women have familiar nicotine intoxication, which adversely affects the health of a pregnant woman with asthma and her fetus under constant hypoxia.

The role of nuclear factor kappa B (NF-kB) and cytokines in the formation of placental insufficiency in 64 pregnant women with obesity and hypothalamic dysfunction (the main group) was studied. 30 relatively healthy women made the control group. The level of TNF-α, IL-1β and IL-10 were defined in the homogenate of placenta (38-40 weeks). In all cases the morphological study of placenta was done with electronic-microscopic and histological methods. The pregnant women of the main group in comparison with the control one were revealed to have the increase of TNF-α till 68.7±0.79 pg/mL (p=0.007) and of IL-1β till 93.7±0.92 pg/mL (p=0.021) in the homogenate of placenta, the reduction of IL-10 till 19.7±1.02 pg/ml (p=0.000), against 1.2 times increase in the activity of NF-kB factor (р=0.007), which was accompanied by a violation of maturation of chorionic villi, involutive and degenerative changes in the structure of the chorion, microcirculatory disturbances. The obtained results indicate that the development of placental insufficiency in obese women with hypothalamic dysfunction are associated with immune changes caused by the activation of NF-kB followed by the release of cytokines which influence the processes of angiogenesis, coagulation and apoptosis in placenta, with the formation of the primary and under the failure of compensatory processes chronic placental insufficiency.

Maternal infections entering fetus and placenta via ascending pathways are a class of their own among the numerous causes of habitual miscarriage. Prevalence and spectrum of pathogens of perinatally significant infection in placenta in habitual miscarriage were identified by PCR method. We found that placentas in incomplete pregnancies were infected in 62.8% of cases, or 1.7 times more than the rate in full-term pregnancies (37.5%; р<0.05). Placental infection was found in women with compromised gynecology history (spontaneous abortions, IVF, endocrine disorders) and pregnancy complications (fetal hypoxia, growth retardation, placental insufficiency). Most frequent pathogens in habitual miscarriage cases were Streptococcus pneumoniae (34.0%), Ureaplasma urealyticum (32.5%) and Cytomegalovirus (16.3%). The rate of pneumococcus and cytomegalovirus isolation was 8.9 and 4 times lower than that in full-term pregnancy, respectively (р<0.05). The difference in the rate of Ur. urealyticum infection of placentas in full-term and incomplete pregnancy was not significant. Such pathogens as Mycoplasma hominis, Mycoplasma genitalium, Herpes human virus 4 type, Herpes human virus 6 type, Streptococcus pyogenes, Streptococcus agalactiae, Pseudomonas aeruginosa, and Staphylococcus aureus were only isolated in single cases.

The aim of the research is to define the state of SH-group activity in syncytiotrophoblast of chorion villi under the relapse of cytomegalovirus infection (CMVI) at the stage of pregnancy of 5-7 weeks. To estimate the activity of SH-group identified by Barrnett-Seligman method 15 villous chorions of 8-9 weeks obtained at the medical abortion from women with the relapse of CMVI (IgG antibody titer was 1:1600) at the stage of 5-7 weeks were studied. The control group included 15 villous chorions from CMV-seronegative women at the same stages of pregnancy. The analysis of paraffin section dyed by Barrnett-Seligman method was done by cytophotometric method by Scion program. As a result of the study the decrease of SH-group concentration was found out in the outer membrane of syncytiotrophoblast of chorion villi under CMVI relapse (IgG antibody titer was 1:1600) at the stage of 5-7 weeks till 10.6±0.4 arb. units (the control was 20.5±0.8 arb. units, p<0.001). Thus, the expression of CMV at the surface of chorion villi syncytiotrophoblast which is the most evident during the relapse of infection is associated with the decrease of SH-group concentration and the disturbance of trophic processes in fetoplacental barrier at the early stages of embryo development.

To identify the dynamics of changes of рСО₂ and its influence on hemoglobin oxygenation the blood of 45 seropositive to cytomegalovirus pregnant women (the main group) and 45 seronegative pregnant women (the control group) was studied taking into account the gestation period when the recurrence of cytomegalovirus infection took place (9-12^th, 18-21^st and 30-34^th weeks). Using spectrophotometry 2.3-DPG, ATP, oxyhemoglobin, methemoglobin, the coefficient of hemoglobin oxygen affinity were studied. Blood gases were identified at biochemical analyzer. In the blood of pregnant women depending on the gestation period when there was cytomegalovirus infection recurrence there was statistically significant increase of рСО₂, methemoglobin, 2.3-DPG, the coefficient of hemoglobin oxygen affinity at the simultaneous drop of рСО₂, ATP and oxyhemoglobin with the maximal manifestation at 9-12^th weeks (р<0.001). The obtained data show that the recurrence of cytomegalovirus infection especially at 9-12^th weeks leads to the disturbance of morphofunctional state of blood erythrocytes of pregnant women and their ability to oxygenation, the decrease of oxygen exchange processes between the blood of a mother and a fetus, contributing to the threat of intrauterine fetus hypoxia development.

The aim of the research is to develop histochemical method of estimation of carbonic anhydrase in blood erythrocytes to predict the development of hemic hypoxia in pregnant women under the relapse of cytomegalovirus infection (CMVI) at the 8-9^th weeks. 40 women were examined, including 25 women with CMV-seropositive pregnant women with the relapse of CMVI at the 8-9^th weeks and 15 seronegative pregnant women at the same gestation stage. CMV verification, the identification of type-specific antibodies of IgM and IgG, of avidity index was done by the method of immune-enzyme analysis, of CMV DNA by PCR method, of carbonic anhydrase in blood erythrocytes by Kurate method (in the modification of M.T.Lutsenko, I.A.Andriyevskaya), of oxyhemoglobin concentration by the method of Malloy-Evelyn. As a result there was found the decrease of the number of blood erythrocytes in pregnant women under the relapse of CMVI at the 8-9^th weeks till 65.0±2.2% (in the control it was 85.0±3.2%, p<0.001), who had a response to carbonic anhydrase at the level of 0.015±0.002 arb. units (in the control it was 0.059±0.004 arb. units, p<0.001), and the decrease of oxyhemoglobin concentration till 93.0±1.5% (in the control it was 99.0±1.0%, p<0.001). Thus, the development of hemic hypoxia of pregnant women under the relapse of CMVI at the 8-9^th weeks is conditioned by the suppression of carbonic anhydrase activity in erythrocytes, which leads to the accumulation of aminoformic complexes, the decrease of hemoglobin oxygen affinity and the formation of oxyhemoglobin.

The studies to identify the triplet oxygen species in liver homogenate were done; its ability to produce the reactive oxygen species in vitro under introduction to laboratory animals against short-term cold pressure of neostigmine which accumulates in the tissues endogen acetylcholine by anticholinesterase mechanisms. The obtained data were compared with the results of experiments of identifying triplet oxygen species in liver homogenate, its ability to produce reactive oxygen species in vitro under introduction into the liver tissue of acetylcholine in situ. It was found out that short-term cold pressure increases the concentration of triplet oxygen species in liver tissue of animals and increases the ability of liver homogenate to produce reactive oxygen species. The introduction of neostigmine increases only the ability of liver homogenate to produce reactive oxygen species, which is proved by the changes of extinction of the solution containing tetranitrotetrazolium blue of incubation medium. The exogenic introduction of acetylcholine in the tissue of the liver in the molar concentration of 1.1×10^-4 М increases the concentration of the triplet oxygen species, improves the ability of liver homogenate to produce reactive oxygen species, which is proved by the restoration of tetranitrotetrazolium blue in the incubation medium.

The lecture represents a principle of antiviral immunity development at the molecular-cellular level. The antiviral immunity forms a response to the infectious process through an activity of cellular receptors and mediators of intercellular processes (interleukins). The research describes cellular mechanisms which play the main role in antiviral immunity formation. These mechanisms involve intercellular activity of viruses and are supported by functional activity of specific cytotoxic T-lymphocytes, T-effectors and macrophages. The research focuses on the main phases of humoral mechanism of antiviral response, forms of antibodies effect against virions. The conducted analysis describes the activity of a complex of nonspecific factors of resistance and adaptive immunity of the human body, considering modification of pathogenesis of viral infection. The analysis leads to a better understanding of the ways of interaction of viruses with the human body, confrontation features of the immune system to viruses, and formation of antiviral immunity.