Spirometry, body plethysmography and elastic features of lungs examined with the esophageal probe were analyzed in 590 patients with interstitial lung diseases. Spirometry was informative for obstructive symptoms recognition in patients with interstitial lung disease. In 80% of cases decreased Tiffeneau test and normal vital capacity corresponded to obstructive disorders which were confirmed by a comprehensive examination. At the same time, spirometry was not informative in detecting restrictive syndrome as the spirometry tests were not normal only in 52% of patients with this variant of ventilation disorders. In the diagnosis of mixed disorders the predictive ability of spirometry was even lower: the simultaneous decrease of vital capacity and Tiffeneau test were found only in 37% of cases of mixed pattern.

Clinical-laboratory features of the disease course in 60 patients with chronic obstructive pulmonary disease (COPD) associated with intestine dysbacteriosis were studied. In the 1^st group there were 16 patients who did not take antibacterial drugs during a year, the 2^nd group was made of 44 patients who took antibiotics because of COPD exacerbation or because of intercurrent diseases. While studying the microflora of intestines the correlation between intestine dysbacteriosis and the intake of antibacterial drugs was found: in all cases dysbacteriosis was identified, and in the 2^nd group dysbiosis of II and III degree happened oftener (р<0.05). The study of microflora with lavage fluid of bronchi, the identification of the degree of its bacterial content were done to all the patients with the method of sector inoculation. The patients of the 2^nd group at the study of lavage fluid had the associations of microorganisms oftener. The reverse correlation dependence between the intestine dysbacteriosis intensity and inoculation of bronchi mucosa was found out. The patients of the 2^nd group had more intensive inflammation in bronchi. The dependence of the inflammatory process intensiveness in the bronchial tree, the concentration of neutrophils in lavage fluid on the severity of dysbiotic changes in intestines was revealed. The immune status of the patients with COPD associated with the intestine dysbacteriosis was characterized with the decrease of the indices of cellular and humoral part of the immunity and neutrophil phagocytic rate, and the changes were more intensive in the patients of the 2^nd group. The obtained data prove the serious damage of biocenosis in the body of COPD patients. The identified features dictate the necessity to correct the damage and conduct a personal therapy.

Objective: to study the degree of negative impact of chronic obstructive pulmonary disease (COPD) on the quality of life of patients from different age groups. The quality of life was studied in 86 patients with COPD in remission. The main group consisted of the older patients (the mean age is 64.92±3.51 years old), the comparison group included mature patients (the mean age is 41.99±2.81 years old). The assessment of the quality of life was done by the results obtained from the questionnaire «Medical Outcomes Study Short Form-36» (MOS SF-36) and specialized questionnaire «St. George's Respiratory Questionnaire» (SGRQ). According to the results of the research, older patients were characterized by a decrease in the quality of life in the majority of scales of the common questionnaire MOS SF-36 compared with mature patients. Statistically significant reductions were in the scales characterizing the physical and psychosocial status of elderly patients. When analyzing the SGRQ specific quality of life questionnaire results, a more significant effect of the disease on the overall health of older patients was found out, which was confirmed by a higher «total score». Thus, the results of general and specialized questionnaires showed that the age is one of the most important factors determining the reduced quality of life of COPD patients in remission.

A multivariate analysis in long-term prevention of disorders of lung function parameters was done among the patients - non-residents of the North with chronic obstructive pulmonary disease (COPD) of II-IV stage with comorbid conditions. 46 COPD patients with comorbid conditions who received a complex rehabilitation program (main group) and 39 patients of control group who received a usual prophylactic program were studied in dynamics. During 10 years the clinical manifestations and spirography indices were assessed. Lung function significantly increased in the main group in contrast to the control group: vital capacity (VC) became 1.3 times more (p<0.001), the forced expiratory volume at the 1^st second (FEV₁) became 1.1 times more (p<0.05), maximal expiratory flow at 75% of VC (MEF₇₅) was 1.7 times more (p<0.001) and the total volume (rX) decreased from 104728.0000 to 19250.0000 and the overall asymmetry (vX) from 9.8949 to 8.2083. It indicates that there is the stabilization of the functional system and the positive effect of the developed program of patient management in the main group. In the main group acute cardiovascular events (p<0.001) and decompensated chronic pulmonary heart (p<0.05) develop much less than in control. The number of exacerbations of COPD was 3.3 times less (p<0.001), the proportion of patients with disabilities of 2 and 3 group decreased (2.2 times less).

The aim of the research is to study the thrust (atypical) course of infiltration of lung tissue in 125 patients of pulmonary hospital. All the patients underwent chest radiography on admission and after two weeks of treatment. In the absence of positive dynamics the bronchoscopy was performed. In 49.6% of cases persistent pulmonary infiltration is associated with the tumor process, in 17.6% with tuberculosis, in 11.2% chronic bronchial strange bodies were identified. In 16% of cases certain clinical background became the cause of the lack of positive dynamics of infiltrative process: chronic obstructive pulmonary disease and chronic renal failure. In 4% of cases the resistant pulmonary infiltration was due to atypical bacterial flora. Thus, most cases of persistent course of infiltrative process in the lungs were associated with tumor or tuberculosis processes. The second most important cause is the presence of certain clinical background which contributes to lingering pneumonia.

The study of lethality from venous thrombo-embolic complications was done for three years by the results of pathological-anatomical examinations of 1764 patients. Age, sex, the season of the year, the main disease because of which the patient was in hospital, the dates of death since the moment of the patient getting to hospital, the sources of the initial thrombi formation, the changes in the pulmonary tissue, the level of obturation of pulmonary venous bed by embologenic masses were considered. It was found out that in 5.4% of the patients the cause of the death was venous thrombo-embolic complications: 0.8 per 1000 of population a year. The mean age of patients who died from thromboembolism of pulmonary artery is 58 years, by the sex parameter women dominated (58%). The structure of pathology because of which patients had the treatment in hospital is the following: postoperative period after multiprofile surgeries (31%), severe disorders of brain blood circulation (32%), multiprofile therapeutic pathology (37%). 20% of patients died from massive thromboembolism of pulmonary artery at the first day after it happened, 25% died in 2-7 days, 57% died at the 7^th day or in several months. The source of the first thrombi formation in 52% of patients became venous sinuses of anticnemion, in 22% it was popliteus-thigh-iliac segment and low cava, in 10% these were the right compartments of heart, in 16% the source was not identified. In 2/3 of patients there was an acute obturation of the pulmonary trunk and of main branches of the pulmonary artery. The ways of prevention of the formation of venous thromboembolic complications and massive thromboembolism of the pulmonary artery in hospital patients of the Amur region were developed

In conditions of the educational institution 4 groups of children (at the age of 13-14 years old) were examined; each group consisted of 15 children. In the first group the prophylaxis was carried out by the application of eleutherococcus extract at one drop per life year a day during 28 days, in the second group rhodiola rosea extract was applied (1 drop per life year, 28 days), in the third group the children took hypericum tincture 10 ml per life year during 28 days, the fourth group was the control one (phytopreparations prophylaxis was not applied). The sanitation course was held during autumn-and-winter period (November, January). After the experiment ended the children’s attendance in every group was observed and the content of lipid peroxidation products against major constituents of antioxidant system in children’s blood plasma was studied. The research results showed that in the first and the third groups the number of children with poor attendance was significantly smaller as compared with the control group. Consequently, the possibility of application of eleutherococcus and hypericum in prophylaxis of respiratory apparatus diseases among children of adulthood is proved. The examination of the content of lipid peroxidation products in children’s blood plasma showed that the application of phytopreparations causes the significant decrease of lipid hydroperoxides content in blood plasma of children taking rhodiola and hypericum (by 27.7% and 24.1%, respectively, as compared with the control group). The content of malonic dialdehyde in blood plasma of all experimental groups is lower than in the control group: in the group where eleutherococcus was applied by 12.1%, rhodiola rosea by 17.3%, hypericum by 10.4%. The content of diene conjugates in groups where phytopreparations were applied is lower than in the control group: in the group where eleutherococcus was applied by 13.3%, rhodiola rosea by 38.8%, hypericum by 28.7%. The content of major constituents of the antioxidant system in blood plasma of children who took phytopreparations is higher in all experimental groups as compared with the control group. The experiment results show that the application of phytopreparations leads to the decrease of process intensity of peroxidation by means of decrease of the content of major constituents of lipid peroxidation - lipid hydroperoxides, diene conjugates, and malonic dialdehyde. For reasons given, it can be stated that one of the reserves of disease incidence decrease in educational institutions is directed sanitation of children with the application of phytopreparations.

Hypoxia influences badly the tissue metabolism of many organs. The aim of the research was to study the influence of respiratory hypoxia on the changes of metabolism in the wall of bronchi in patients with bronchial asthma (BA). 73 BA patients including 25 patients with mild persistent course of the disease, 23 with moderate asthma, 25 with severe BA, were examined. Ventilation pulmonary function was assessed by the data obtained from the curve «flow-volume» of the forced expiration. In the peripheral blood acid-alkalotic state of blood gases, the level of oxyhemoglobin, the content of carbonic anhydrase, 2.3-diphosphoglycerate and ATF, histamine and serotonin were determined. The concentration in bronchi mucosa of fatty acids peroxides, histamine and glycosaminoglycans was identified with histochemical methods. It was found out that in BA patients as a result of the formation of bronchoobstructive syndrome and the disturbance of bronchial conductance the oxygen saturation of the venous blood decreases. When there is stable hypoxemia in the peripheral blood, acid-base balance is damaged, and in peripheral blood erythrocytes there is the decrease of hemoglobin oxygenation. This forms the disorder of tissue metabolism as to the tissue cells the blood is delivered with the low concentration of oxygen. The composition of bronchi mucosa changes. In epithelial cells by histochemical methods the increased number of histamine and fatty acids peroxides was revealed, which leads to the destruction of cells. This process maintains a severe course of asthma.

The morphological changes in the respiratory system with drug-resistant fibro-cavernous pulmonary tuberculosis were studied. The material taken from 90 dead patients at the age of 25 to 70 years old, 36 of whom died of fibro-cavernous pulmonary tuberculosis with multidrug resistance, were examined. Those who died of fibro-cavernous tuberculosis with drug sensitivity became the control group. A number of features that characterize the morphological changes in the drug-resistant fibro-cavernous pulmonary tuberculosis were found out. They are revealed through the formation of giant caverns, significant increase in the volume density of caseous necrotic component, specific lesion of lobar and segmental bronchi in 96% of cases. In lymph nodes against hyperplasia of lymphoid tissue there is a dramatic atrophy of lymphoid follicles with the reduced number of T and B lymphocytes, which is a reduction of morphological features of cellular immunity. These changes are most conspicuous in groups with multidrug-resistance and multi-resistance at the duration of the disease from 1 to 5 years.

The blood supply and ultrasound picture of fetoplacental complex, the concentration of secretory immunoglobulin A, circulatory immune complexes and the level of endotoxemia in 53 women at exacerbation of chronic nonobstructive and obstructive bronchitis in III trimester of gestation were studied. The first group included 28 patients with exacerbation of chronic nonobstructive bronchitis, the second one had 25 women with exacerbation of chronic obstructive bronchitis. 25 women with physiologic course of pregnancy became the control. It was found out than in III trimester of gestation in women of the 2^nd group there was the rise of the vessel resistance in the right uterine artery till 3.06±0.08 relative units, in the umbilical artery till 3.86±0.08 relative units, and in the medial cerebral artery till 5.31±0.10 relative units in comparison with the first group where these indices were 2.75±0.10 relative units (р<0.05), 3.59±0.07 relative units (р<0.05) and 5.01±0.08 relative units (р<0.05), respectively. In the second group the thickening of placenta (36.0%) and loop of cord (45.6%) were registered oftener, which changes hemodynamics and optimal conditions of delivering the energetic substrate to the intrauterine patient. In the first group these parameters were 7.1% (p<0.05) and 7.1% (р<0.05), respectively. At the same time the concentration of secretory immunoglobulin A decreased till 3.2±0.23 g/L at the rise of the concentration of circulatory immune complexes till 0.23±0.005 units of optical density and mean molecular peptides till 0.288±0.005 units of optical density. In the first group the indices were 5.2±0.44 g/l (р<0.001), 0.20±0.003 units of optical density (р<0.001), 0.274±0.004 units of optical density (р<0.05), respectively. This proved the worsening of local immune protection of airway mucosa, autoimmune restructuring of the mother’s organism and endotoxemia, all of which increase the conductance of hematoplacental barrier for germs and their toxins as well as the risk of damage of endothelial lining of blood vessels of the system «mother-placenta-fetus».

The purpose of this study was to investigate the activity of lipid peroxidation in relation to the content of the proinflammatory cytokine of tumor necrosis factor alpha (TNFα) at cytomegalovirus infection (CMVI) in the III trimester of gestation, depending on the titer of IgG antibodies to cytomegalovirus (CMV). A total of 60 pregnant women in the III trimester of gestation, aged 21-38 years, and diagnosed with chronic CMVI were examined. The patients of the main group were divided into two subgroups: subgroup A - 30 women with reactivation of CMVI (titer of IgG antibodies to CMV 1:1600), subgroup B - 30 women with a titer of IgG antibodies to CMV 1:800. The comparison group included 30 women with physiological pregnancy, comparable by gestational period and age with the main group. After the study we can conclude that the activation of peroxidation recorded by malondialdehyde (MDA) content in the blood serum of pregnant women with CMVI is associated with an increase in the concentration of proinflammatory cytokines - TNFα. These figures depend on the titer of IgG antibodies to CMV. When there is the titer of IgG antibodies to CMV 1:1600, the content of TNFα in peripheral blood of women became 2.7 times more (p<0.001), of MDA 1.8 times more (p<0.001); at titer of IgG antibodies to CMV 1:800 it was 1,5 times (p<0.001) and 1.3 times more (p<0,001), respectively. The data obtained allow us to suggest the possible accession of inflammatory complications and reasonable approach to the choice of tactics for pregnant women with CMVI, i.e. to conduct detoxification therapy.

Using biochemical methods, the functional state of hepatobiliary system at moderate cerebral ischemia was studied in 115 mature newborns from mothers with chronic cytomegalovirus infection (CMVI) against chronic herpes-virus infection in the second trimester of pregnancy. The control was made of 30 healthy newborns, the group of comparison consisted of 25 newborns from mothers with chronic CMVI in II trimester of gestation (there was the absence of antibody titer of IgM to cytomegalovirus (CMV), IgG antibodies to CMV were 1:200 and avidity index IgG to CMV was 56-70%). In the newborns with moderate cerebral ischemia whose mothers had reactivation of chronic CMVI in II trimester of gestation (antibodies of IgG to CMV are 1:200-1:400, IgG antibodies to CMV are 1:200-1:800 and avidity index of IgG to CMV is 56-70%) in comparison with the control there was the decrease of the general protein till 54.2±1.10 g/L and albumins till 34.4±1.01 g/L against the increase of bilirubin concentration: of general one till 35.9±1.59 mcmole/L, of unconjugated one till 33.6±1.58 mcmole/L and of conjugated one till 2.27±0.10 mсmole/l (in the control group they are 60.9±1.39 g/L, р<0.001; 38.0±1.15 g/L, р<0.05; 25.4±1.67 mcmole/L, р<0.001; 23.3±1.66 mcmole/L, р<0.001; 1.87±0.09 mcmole/L, р<0.01, respectively), which suggested the inhibition of protein synthesis and inconsistency of pigment exchange. At the same time there was the increase of activity of alkaline phosphatase till 170.6±9.11 МЕ/L (in the norm it is 142.0±6.39 МЕ/L, р<0.05), which was typical for the development of cholestasis. Moderate cerebral ischemia in newborns from mothers with chronic CMVI reactivation (antibody titer of IgM to IgM CMV is 1:200-1:400, the growth of antibody titer of IgG to CMV is 1:400-1600 and avidity index of IgG to CMV is 56-70%) in comparison with the same perinatal pathology in babies from mothers with the exacerbation of the infection (the antibody titer of IgM to CMV is 1:200-1:400, the antibody titer of IgG to CMV is 1:400-800 and avidity index of IgG to CMV is 56-70%) led to the increase of alkaline phosphatase activity till 188.5±10.5 МЕ/L (р<0.05), which indicates more intensive cholestasis.

The aim of the work is to give clinical and pathomorphological characteristic of severe cerebral ischemia in newborns with antenatal parainfluenza and mixed-respiratory virus infection. Echographic indices of the brain and the blood flow in the mean brain artery at severe cerebral ischemia were studied in 27 mature newborns; the composition of soft brain tunic, brain cortex, brain substances, ependymas and choroid plexus of lateral ventricle were examined in 14 dead babies with intrauterine parainfluenza of 1 and 3 types (the first group) and in 23 babies with mixed-respiratory virus infection (the second group). The control group included 30 healthy mature newborns and 25 newborns of 38-40 weeks with uncomplicated antenatal anamnesis who died from the birth trauma. It was found out that in the second group in comparison with the first group the frequency of central nervous system depression increased till 39.1% and in 34.8% of children there was subarachnoidal hemorrhage. In the first group such changes happened in 7.4% (р<0.05) and in 3.7% (р<0.05) of newborns, respectively. In the second group there was the increase of the vessel resistance in the medial cerebral artery till 0.79±0.03 relative units (in the first group it is 0.70±0.02 relative units, р<0.05). At antenatal mixed-respiratory virus infection there were intra ventricle hemorrhages with pathomorphological identification of liquid blood in the cavity of the front and back horns of lateral ventricles (in 3 newborns) as well as significant desquamation of ependymocytes. Died children often had vasculitis, perivascular hemorrhages, intensive plephora of capillary tubes with proliferation of their endotheliocytes in choroid plexus of lateral ventricles as a result of direct and indirect influence of several respiratory viruses on membrane structures of cellular elements.

The purpose of this study was to investigate the mechanisms of effect of inhaled mixture made on the basis of bee royal jelly and propolis (apingalin) in experimental pulmonary edema. Studies were conducted on adult rats (male) with the weight of 0.18-0.2 kg; the rats were divided into groups: intact animals, control animals with adrenal experimental pulmonary edema, experience animals with pulmonary edema; all of them then inhaled apingalin. The bodies for morphological and biochemical analyses were collected one day after the termination of the experiment. In preparations of isolated trachea of rats, the reaction of constriction-relaxation after adding apingalin was studied. When studying the therapeutic effect of the mixture, the weight ratio and dry residue were measured; the histological examination of lung tissue was done. The activity of the process of lipid peroxidation was assessed by the content of diene, triene conjugates and Schiff bases in lung homogenates; oxidized protein modification was estimated in terms of carbonyl derivatives. It was found that the effect of the drug on the basis of royal jelly and bee propolis on isolated tracheal preparation is biphasic: the first one is a short-term phase of constriction of the preparation, and the second one is a long-term phase of its relaxation mediated through the activation of beta-adrenergic receptors. Course of 10-day inhalation of apingalin reduces the amount of oxidized forms of the protein and prevents the oxidation of lipids in the lung tissue of rats.

In experimental conditions the possibility to correct free radical lipid oxidation of rats’ organism membranes was studied with the oral introduction of the phytoadaptogens that contain the complex of natural antioxidants. The animals were divided into 9 groups and each of them had 10 rats: intact animals (1) which were held in standard conditions of vivarium; the control group (2) in which rats were exposed to cold during three hours daily; the control group (3) in which rats were exposed to ultraviolet radiation during three minutes daily; the experimental groups (4, 6, 8) in which before cooling animals had a daily oral intake of the tincture ginseng, of the tincture schizandra, of the tincture aralia in a dose of 1 mL/kg; the experimental groups (5, 7, 9) in which before ultraviolet radiation animals had a daily oral intake of the tincture ginseng, of the tincture schizandra, of the tincture aralia in a dose of 1 ml/kg. It is established that daily cold exposure during three hours and daily ultraviolet radiation during three minutes contribute to the decrease of rats’ organism stability to physical activities, to the increase of lipid hydroperoxides level (by 44-52%), of diene conjugate (by 49-58%), and of malonic dialdehyde (by 38-46%) against the decrease of antioxidant system activity in the blood of intact animals. The introduction of phytoadaptogens to rats in the conditions of oxidative stress contributes to the increase of the duration of rats swimming by 13-24% in 7 days of the experiment results, to the reliable decrease in the blood of lipid hydroperoxides by 10-28%, of diene conjugates by 16-27%, malonic dialdehyde by 20-29% in comparison with the rats of the control groups. While analyzing the effect of the phytoadaptogens on the activity of the components of antioxidant system it was shown that the level of ceruloplasmin in the blood of animals was reliably higher by 26-42%, of vitamin E by 25-32% in comparison with the same parameters of the rats of the control groups. So, the application of the mentioned phytoadaptogens in the conditions of oxidative stress induced by the influence of cold and ultraviolet rays leads to the stabilization of the processes of peroxidation against the increase of antioxidant system activity.

The experimental research to determine the content of diene conjugates and common hydroperoxides in the fraction of total lipids of the liver and of malondialdehyde in liver homogenate was done at the introduction of acetylcholine in situ in the rats liver tissue. It was found out that the introduction of acetylcholine in situ in liver tissue in the molar concentration of 1.1×10^-3 M increases and in the molar concentration of 1.1×10^-4 M, 1.1×10^-5 M, 1.1×10^-6 M reduces the content of diene conjugation and methyl esters of fatty acids C_{20: 4} Δ 5,8,11,14 eicosatetraenoic (arachi) and C_20:5 Δ 5,8,11,14,17 - eicosapentaenoic (eicosa). The introduction of acetylcholine in situ in the liver tissue increases the content of total hydroperoxides and malondialdehyde, but reduces the concentration of α-tocopherol.

The article is devoted to the research of atmospheric suspensions of settlements of the Primorsky region: Dalnegorsk, Luchegorsk, Rudnaya Pristan by means of laser granulometry and mass spectrometry of high resolution. For control the border zone of the Sikhote-Alinsky Biospheric Reserve has been chosen. In Dalnegorsk and Rudnaya Pristan the prevalence in snow of firm particles up to 10 microns in size from 54 to 100% is recorded. In Dalnegorsk in snow in a water-soluble phase there is a big quantity of Fe, Ni and Cu, and near the enterprise «Bor» of Zn. In a water-soluble phase of the samples which were taken in Rudnaya Pristan, high concentration of Pb was revealed. In Luchegorsk near Regional Power Station microparticles of 10-18 microns in size in the proportion of 72% were found out, and in a water-soluble phase there was a sharp increase of Zn concentration, and moderate increase of Pb, Al and Fe. In two points on border with Sikhote-Alin Biosphere Reserve large firm particles (515.46-954.78 microns) were found and only in one point adjoining a highway there was the prevalence of microparticles (9-20 microns). Also there was high concentration of Zn in one of the points on the border with the reserve. It proves the fact that technogenic factors influence the conservation zone more and more.

10 strains of Penicillium mold fungi which at 24...+29ºC form a complex of extracellular cellulases destroying paper were isolated from industrial mining wastes containing high concentrations of various heavy metals. Simultaneously these strains synthesize and excrete penicillin antibiotic. The most active producers were P. citreo-viride and P. canescens : the first one excreted 122.9 mcg/mL of penicillin, the second one 30.72 mcg/mL. This suggests new opportunities of their practical application in bioctechnology.

In standard classifications of interstitial pulmonary diseases alveolar pulmonary proteinosis (APP) by etiologic signs is referred to the group of idiopathic ones, where besides APP there is sarcoidosis, idiopathic pneumofibrosis, Hand-Schuller-Christian disease, idiopathic interstitial alveolitis (acute interstitial pneumonia, Hamman-Rich syndrome) and others. APP is a rare but potentially curable disease of unknown etiology, characterized by the disorder of surfactant metabolism, which leads to accumulation of protein in alveoli (superficially active substances) and its components, including phospholipids. The main feature of APP (and this is definitely taken into account in diagnostics) is its poor clinical picture which does not correspond to large pulmonary damages registered in roentgenograms and at multispiral computer-aided tomography (MSCT) with post processing image processing. This article gives a review of recently published domestic and foreign literature. During 5 years we examined, treated and observed in dynamics 6 patients with APP. This report presents one research whose feature is the wrong clinical diagnosing of the disease at all preliminary stages of examination of the patient with APP. Because of clinical mistakes open biopsy was done in a wrong way, without special painting of biopsy material upon the presence of protein components. As a result of system mistakes several courses of improper therapy were done, which led to complications of the disease in the form of recurrent pneumonia. Final clinical-radiologic examination allowed to diagnose autoimmune form of APP, and the repeat open biopsy with the painting of biopsy material with Schiff's reagent (PAS-reaction) gave us a chance to make a final diagnose. At dynamic monitoring with the help of MSCT in 6 months this patient had almost complete spontaneous APP remission.

The material is dedicated to the topical issue of Anxiodepressive Disorders of Chronic Obstructive Pulmonary Disease (COPD) patients. By 2020, as WHO experts predict, depression will become one of the most common incapacity reasons, coming second after cardiovascular disease. According to the modern conceptions, COPD is a systemic disease with cardiopulmonary effects, among which anxiety and depression disorders have a significant role and worsen the prognosis. According to various researches, psychological pathology morbidity of COPD patients is registered in 8-49% of cases. The considerable indices scatter is explained by the fact that clinicians frequently examine anxiety and depression disorders collaboratively or they apply only psychometric scale or combine anxiety with other conditions. The underestimation of such information can significantly limit the patient’s life quality, thus worsening the state and prognosis of a prior disease. As for cognitive deteriorations under COPD, they take place in 27-62% of cases. The main cognitive deteriorations predictors are common for the whole population - age and education level, special for COPD - hypoxemia and smoking. One of the considered problem promising directions is the detection of prior predictors which have an impact on the formation of anxiety, depression and cognitive deteriorations of COPD patients, and also the search of new treating depression schemes for the patients with such a pathology.